ArticleNutrients2019
Effect of Lipid Emulsion on Stability of Ampicillin in Total Parenteral Nutrition.
Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Development and Characterization of Intravenous Nanoemulsions Loaded withMolecules (Basel, Switzerland) · 2026Article
- Harnessing algae oil as a sustainable DHA source for parenteral nutrition in vegan patients.Scientific reports · 2025Article
- Development and Validation of In Vitro Assessment Protocol of Novel Intravenous Nanoemulsions for Parenteral Nutrition.Pharmaceutics · 2025Article
- Article
- Physicochemical Compatibility of Ceftolozane-Tazobactam with Parenteral Nutrition.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Y-Site Compatibility Studies of Parenteral Nutrition and Other Intravenous Medications in Neonatal and Pediatric Patients: A Review of the Literature Evidence.Pharmaceutics · 2024Review
- Use of Total Parenteral Nutrition (TPN) as a Vehicle for Drug Delivery.Current drug targets · 2024Review
- Honokiol-Loaded Nanoemulsion for Glioblastoma Treatment: Statistical Optimization, Physicochemical Characterization, and an In Vitro Toxicity Assay.Pharmaceutics · 2023Article
- Sodium Valproate Incompatibility with Parenteral Nutrition Admixtures-A Risk to Patient Safety: An In Vitro Evaluation Study.Pharmaceutics · 2022Article
- All-in-One Pediatric Parenteral Nutrition Admixtures with an Extended Shelf Life-Insight in Correlations between Composition and Physicochemical Parameters.Pharmaceutics · 2021Article
- Toward Safe Pharmacotherapy: The Interplay between Meropenem and Parenteral Nutrition Admixtures.Antibiotics (Basel, Switzerland) · 2021Article
- Safe Practice of Y-Site Drug Administration: The Case of Colistin and Parenteral Nutrition.Pharmaceutics · 2020Article
- The Interactions between Ciprofloxacin and Parenteral Nutrition Admixtures.Pharmaceutics · 2019Article
- Development, Validation, and Stability Assessment Application of RP-HPLC-DAD Method for Quantification of Ampicillin in Total Parenteral Nutrition Admixtures.Antibiotics (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAmpicillin (AMP) is frequently administered parenterally in critically ill patients with meningitis or endocarditis. Many of them require parallel infusion of total parenteral nutrition (TPN) admixtures. The aim of the study was to determine the physicochemical stability of AMP in TPN admixtures.
methodsAMP was added to two formulations of TPN admixtures differing in the lipid emulsion (Lipofundin
resultsThe addition of AMP as well as vitamins and trace elements to the TPN admixtures did not affect their physical stability. An increase in the pH value of approx. 0.6 and reduction of zeta potential were observed. The MDD of the lipid emulsions was below the limit of 500 nm (dynamic light scattering (DLS) method) and no fat droplets greater than 525 nm were observed (light diffraction (LD) method). The content of AMP after the first 24 h was within the acceptable limit of 90% for TPN admixtures stored at 4 ± 1 °C and 25 ± 1 °C with light protection.
conclusionsThe results showed that co-administration of AMP in the same bag with TPN admixture at the tested dose is possible when used ex tempore and with light protection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.