Evidence map›Paper›PMID 30845661›Full record

ArticleInternational journal of molecular sciences2019

CD99 Expression in Glioblastoma Molecular Subtypes and Role in Migration and Invasion.

Lais C Cardoso, Roseli da S Soares, Talita de S Laurentino, Antonio M Lerario, Suely K N Marie, Sueli Mieko Oba-Shinjo

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 30 citations in OpenAlex.

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  13. Article
  14. CD99 in malignant hematopoiesis.Experimental hematology · 2022
    Review
  15. Article
  16. Review
  17. Genes that escape from X-chromosome inactivation: Potential contributors to Klinefelter syndrome.American journal of medical genetics. Part C, Seminars in medical genetics · 2020
    Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Lais C CardosoLaboratory of Molecular and Cellular Biology (LIM 15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 01246-903, Brazil. laisccardoso@usp.br.
Roseli da S SoaresLaboratory of Molecular and Cellular Biology (LIM 15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 01246-903, Brazil. roselis@usp.br.
Talita de S LaurentinoLaboratory of Molecular and Cellular Biology (LIM 15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 01246-903, Brazil. talitalaurentino@usp.br.
Antonio M LerarioDepartment of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI 48109, USA. alerario@umich.edu.
Suely K N MarieLaboratory of Molecular and Cellular Biology (LIM 15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 01246-903, Brazil. sknmarie@usp.br.
Sueli Mieko Oba-ShinjoLaboratory of Molecular and Cellular Biology (LIM 15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 01246-903, Brazil. suelimoba@usp.br.ORCID 0000-0002-1650-5973
Universidade de São Paulo · BRUniversity of Michigan · US

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 305730/2015-0Faculdade de Medicina da USP no numberFundação de Amparo à Pesquisa do Estado de São Paulo 2001/12898-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2004/12133-6Fundação de Amparo à Pesquisa do Estado de São Paulo 2013/02162-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/03614-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/03995-9
6 · The paper itself

Abstract

Glioblastoma (GBM) is the most aggressive type of brain tumor, with an overall survival of 17 months under the current standard of care therapy. CD99, an over-expressed transmembrane protein in several malignancies, has been considered a potential target for immunotherapy. To further understand this potentiality, we analyzed the differential expression of its two isoforms in human astrocytoma specimens, and the CD99 involved signaling pathways in glioma model U87MG cell line. CD99 was also analyzed in GBM molecular subtypes. Whole transcriptomes by RNA-Seq of

Indexed as

Up-Regulation12E7 AntigenBrain NeoplasmsCell Line, TumorCell MovementFocal Adhesion Kinase 1Gene Expression ProfilingGene Expression Regulation, NeoplasticGene Knockdown TechniquesGenes, srcGlioblastomaHumansNeoplasm InvasivenessProtein IsoformsRNA, Small InterferingSequence Analysis, RNA12E7 AntigenCD99 protein, humanFocal Adhesion Kinase 1Protein IsoformsPTK2 protein, humanRNA, Small InterferingCD99cytoskeletonglioblastomamigrationtranscriptome

Identifiers

PMID30845661
PMCPMC6429353
OpenAlexW2920030348

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.