Evidence map›Paper›PMID 30845657›Full record

ReviewInternational journal of molecular sciences2019

The Usefulness of Immunohistochemistry in the Differential Diagnosis of Lesions Originating from the Myometrium.

Piotr Rubisz, Michał Ciebiera, Lidia Hirnle, Magdalena Zgliczyńska, Tomasz Łoziński, Piotr Dzięgiel, Christopher Kobierzycki

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Diagnostic and prognostic value of Bcl-2 in uterine leiomyosarcoma.Archives of gynecology and obstetrics · 2023
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. CouldBiomedicines · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Leiomyoma with Bizarre Nuclei: A Current Update.International journal of women's health · 2022
    Review
  14. The Management of the Cotyledonoid Leiomyoma of the Uterus: A Narrative Review of the Literature.International journal of environmental research and public health · 2021
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Piotr RubiszFirst Department of Gynecology and Obstetrics, Wroclaw Medical University, 50-368 Wrocław, Poland. piotr.rubisz@gmail.com.
Michał CiebieraSecond Department of Obstetrics and Gynecology, The Center of Postgraduate Medical Education, 01-809 Warsaw, Poland. michal.ciebiera@gmail.com.ORCID 0000-0001-5780-5983
Lidia HirnleFirst Department of Gynecology and Obstetrics, Wroclaw Medical University, 50-368 Wrocław, Poland. lidia.hirnle@umed.wroc.pl.
Magdalena ZgliczyńskaStudents' Scientific Association at the I Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-015 Warsaw, Poland. zgliczynska.magda@gmail.com.
Tomasz ŁozińskiDepartment of Obstetrics and Gynecology Pro-Familia Hospital, 35-001 Rzeszów, Poland. tomasz.lozinski@pro-familia.pl.
Piotr DzięgielDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland. piotr.dziegiel@umed.wroc.pl.
Christopher KobierzyckiDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland. ch.kobierzycki@gmail.com.ORCID 0000-0001-8023-8585

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uterine leiomyomas (LMs), currently the most common gynecological complaint around the world, are a serious medical, social and economic problem. Accurate diagnosis is the necessary prerequisite of the diagnostic-therapeutic process. Statistically, mistakes may occur more often in case of disease entities with high prevalence rates. Histopathology, based on increasingly advanced immunohistochemistry methods, is routinely used in the diagnosis of neoplastic diseases. Markers of the highest sensitivity and specificity profiles are used in the process. As far as LMs are concerned, the crux of the matter is to identify patients with seemingly benign lesions which turn out to be suspicious (e.g., atypical LM) or malignant (e.g., leiomyosarcoma (LMS)), which is not uncommon. In this study, we present the current state of knowledge about the use of immunohistochemical markers in the differential diagnosis of LM, atypical LM, smooth muscle tumors of uncertain malignant potential (STUMP), and LMS, as well as their clinical predictive value.

Indexed as

BiomarkersBiomarkers, TumorCyclin-Dependent Kinase Inhibitor p16Diagnosis, DifferentialFemaleHumansImmunohistochemistryKi-67 AntigenLeiomyomaLeiomyosarcomaMyometriumTumor Suppressor Protein p53Uterine NeoplasmsBiomarkersBiomarkers, TumorCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16Ki-67 AntigenTP53 protein, humanTumor Suppressor Protein p53diagnosisimmunohistochemistryleiomyomaleiomyosarcomamarkermyometriumpathologysmooth muscle tumor of uncertain malignant potentialtumoruterine fibroid

Identifiers

PMID30845657
PMCPMC6429074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.