Evidence map›Paper›PMID 30845374›Full record

ArticleDrug testing and analysis2019

Ethylene glycol: Evidence of glucuronidation in vivo shown by analysis of clinical toxicology samples.

Daniel Sejer Pedersen, Patrick Bélanger, Mikael Frykman, Kirsten Andreasen, Danielle Goudreault, Henrik Pedersen, Peter Hindersson, Torben Breindahl

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug testing and analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daniel Sejer PedersenDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-3926-7047
Patrick BélangerCentre de Toxicologie du Québec (CTQ), Institut National de Santé Publique du Québec (INSPQ), Québec, Québec, Canada.
Mikael FrykmanDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kirsten AndreasenDepartment of Clinical Biochemistry, North Denmark Regional Hospital, Hjørring, Denmark.
Danielle GoudreaultLaboratory of Specialized Biochemistry, Department of Clinical Biochemistry, Optilab Montréal CHUM, building CHU Ste-Justine, Montréal, Quebec, Canada.
Henrik PedersenH. Lundbeck A/S, Valby, Denmark.
Peter HinderssonDepartment of Clinical Biochemistry, North Denmark Regional Hospital, Hjørring, Denmark.
Torben BreindahlDepartment of Clinical Biochemistry, North Denmark Regional Hospital, Hjørring, Denmark.ORCID https://orcid.org/0000-0001-8166-1983

Funding

A.P. Møller Foundation for the Advancement of Medical ScienceAugustinus FondenBrødrene Hartmanns FondLundbeckfondenLundbeck FoundationMarie Pedersen og Jensine Pedersens Legat
6 · The paper itself

Abstract

In the search for improved laboratory methods for the diagnosis of ethylene glycol poisoning, the in vivo formation of a glucuronide metabolite of ethylene glycol was hypothesized. Chemically pure standards of the β-O-glucuronide of ethylene glycol (EG-GLUC) and a deuterated analog (d

Indexed as

BiomarkersChromatography, High Pressure LiquidEthylene GlycolGlucuronidesHumansLimit of DetectionTandem Mass SpectrometryBiomarkersEthylene GlycolGlucuronidesbiomarkerclinical toxicologyethylene glycolglucuronidepoisoning

Identifiers

PMID30845374
PMCPMC6767423

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.