ArticlePloS one2019
Impact of pharmacist-led antibiotic stewardship interventions on compliance with surgical antibiotic prophylaxis in obstetric and gynecologic surgeries in Nigeria.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 8 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Effect of interventions on surgical site infections in Sub-Saharan Africa: a systematic review.BMC surgery · 2025Pooled it
- Improving antibiotic utilization in West Africa: enhancing interventions through systematic review and evidence synthesis.Antimicrobial resistance and infection control · 2025Pooled it
- Antibiotic Use Among Hospitalized Patients in Africa: A Systematic Review of Point Prevalence Studies.Journal of racial and ethnic health disparities · 2024Pooled it
- Association Between Antimicrobial Stewardship Programs and Antibiotic Use Globally: A Systematic Review and Meta-Analysis.JAMA network open · 2023Pooled it
- Pooled it
- Antimicrobial stewardship for surgical antibiotic prophylaxis and surgical site infections: a systematic review.International journal of clinical pharmacy · 2022Pooled it
- A Systematic Review of Pharmacist-Led Antimicrobial Stewardship Programs in Sub-Saharan Africa.International journal of clinical practice · 2022Pooled it
- The Impact of Quality Improvement Interventions in Improving Surgical Infections and Mortality in Low and Middle-Income Countries: A Systematic Review and Meta-Analysis.World journal of surgery · 2021Pooled it
- Impact of antimicrobial stewardship on healthcare-associated infections and antibiotic prescriptions in African countries: Systematic review and meta-analysis.Journal of infection prevention · 2026Review
- Addressing the silent epidemic of antimicrobial resistance in the African region: a scoping review of evidence gaps and research considerations.BMJ public health · 2026Article
- Perioperative Antibiotic Administration Review: An Analysis of Outpatient Surgeries at OhioHealth Doctors Hospital.Cureus · 2025Article
- A Regional Approach to Strengthening the Implementation of Sustainable Antimicrobial Stewardship Programs in Five Countries in East, Central, and Southern Africa.Antibiotics (Basel, Switzerland) · 2025Article
- Article
- Article
- Barriers, facilitators, perceptions and impact of interventions in implementing antimicrobial stewardship programs in hospitals of low-middle and middle countries: a scoping review.Antimicrobial resistance and infection control · 2024Article
- Evaluation of interventions led by pharmacists in antimicrobial stewardship programs in low- and middle-income countries: a systematic literature review.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024Review
- Development of an innovative clinical pharmacy service in a urology surgical unit: a new initiative from Qatar.Journal of pharmaceutical policy and practice · 2024Article
- Knowledge, Perception, and Self-Confidence of Antibiotic Resistance, Appropriate Antibiotic Therapy, and Antibiotic Stewardship Among Undergraduate Pharmacy Students in Sudan.Infection and drug resistance · 2024Article
- Impact of COVID-19 Pandemic on Healthcare-Associated Infections: A Systematic Review and Meta-Analysis.Antibiotics (Basel, Switzerland) · 2023Review
- Impact of the Five-Year Intervention of an Antimicrobial Stewardship Program on the Optimal Selection of Surgical Prophylaxis in a Hospital without Antibiotic Prescription Restrictions in Costa Rica: A Retrospective Study.Antibiotics (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInappropriate and excessive use of surgical antibiotic prophylaxis are associated with the emergence of antibiotic resistance. Antibiotic prophylaxis malpractices are common in obstetrics and gynecology settings and antibiotic stewardship is used to correct such malpractice.
objectiveTo evaluate the impact of antibiotic stewardship interventions on compliance with surgical antibiotic prophylaxis practice in obstetrics and gynecology surgeries.
methodA prospective pre- and post-intervention study was conducted in two tertiary hospitals between May and December 2016. The duration of the each period was 3 months. Antibiotic stewardship interventions including development of a protocol, educational meeting and audit and feedback were implemented. Data were collected using the patient records and analyzed with SPSS version 23.
resultsA total of 226 and 238 surgical procedures were included in the pre- and post-intervention periods respectively. Age, length of stay and estimated blood loss were similar between the two groups. However, specialty and surgical procedures varied significantly. There was a significant increase in compliance with timing (from 14.2% to 43.3%) and duration (from 0% to 21.8%) of surgical antibiotic prophylaxis after the interventions. The interventions significantly reduced the prescription of third generation cephalosporin (-8.6%), redundant antibiotic (-19.1%), antibiotic utilization (-3.8 DDD/procedure) and cost of antibiotic prophylaxis (-$4.2/procedure). There was no significant difference in the rate of surgical site infection between the two periods. Post-intervention group (OR: 5.60; 95% CI: 3.31-9.47), elective surgery (OR: 4.62; 95% CI: 2.51-8.47) and hospital attended (OR: 9.89; 95% CI: 5.66-17.26) were significant predictors of compliance with timing while elective surgery (OR: 12.49; 95% CI: 2.85-54.71) and compliance with timing (OR: 58.55; 95% CI: 12.66-270.75) were significantly associated with compliance to duration of surgical antibiotic prophylaxis.
conclusionThe interventions improve compliance with surgical antibiotic prophylaxis and reduce antibiotic utilization and cost. However, there is opportunity for further improvement, particularly in non-elective surgical procedures.
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