ArticlePloS one2019
Graphene oxide in zinc alginate films: Antibacterial activity, cytotoxicity, zinc release, water sorption/diffusion, wettability and opacity.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 79 citations in OpenAlex.
- Hybrid Alginate-Graphene Composites: Biochemical Features and Biomedical Potential.Marine drugs · 2025Article
- Porous Osteoplastic Composite Materials Based on Alginate-Pectin Complexes and Cation-Substituted Hydroxyapatites.Polymers · 2025Article
- Moderation of cross linkage of sodium alginate-polyethylene oxide films loaded with natamycin for treatment of Aspergillus fumigatus keratitis.Journal of materials science. Materials in medicine · 2025Article
- [A polylactic acid/hydroxyapatite/scholzite composite scaffold for promoting healing of osteoporotic bone defects in rats].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Article
- Biocompatible Chitosan Films Containing Acetic Acid Manifested Potent Antiviral Activity against Enveloped and Non-Enveloped Viruses.International journal of molecular sciences · 2023Article
- Biocompatible Alginate Film Crosslinked with CaACS omega · 2023Article
- Scaffolds in the microbial resistant era: Fabrication, materials, properties and tissue engineering applications.Materials today. Bio · 2022Review
- Engineering alginate hydrogel films with poly(3-hydroxybutyrate-co-3-valerate) and graphene nanoplatelets: Enhancement of antiviral activity, cell adhesion and electroactive properties.International journal of biological macromolecules · 2022Article
- Nanomaterials-Based Combinatorial Therapy as a Strategy to Combat Antibiotic Resistance.Antibiotics (Basel, Switzerland) · 2022Review
- Effect on the Properties of Edible Starch-Based Films by the Incorporation of Additives: A Review.Polymers · 2022Review
- Designing a new alginate-fibrinogen biomaterial composite hydrogel for wound healing.Scientific reports · 2022Article
- Review
- Alginate: Enhancement Strategies for Advanced Applications.International journal of molecular sciences · 2022Review
- Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses Such as SARS-CoV-2.Polymers · 2022Article
- Recent Advances in Metal-Based Antimicrobial Coatings for High-Touch Surfaces.International journal of molecular sciences · 2022Review
- Article
- Graphene and its derivatives: understanding the main chemical and medicinal chemistry roles for biomedical applications.Journal of nanostructure in chemistry · 2022Review
- Poly(lactic acid)/Zinc/Alginate Complex Material: Preparation and Antimicrobial Properties.Antibiotics (Basel, Switzerland) · 2021Article
- Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alginate is considered an exceptional biomaterial due to its hydrophilicity, biocompatibility, biodegradability, nontoxicity and low-cost in comparison with other biopolymers. We have recently demonstrated that the incorporation of 1% graphene oxide (GO) into alginate films crosslinked with Ca2+ cations provides antibacterial activity against Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis, and no cytotoxicity for human keratinocyte HaCaT cells. However, many other reports in literature have shown controversial results about the toxicity of GO demanding further investigation. Furthermore, the synergic effect of GO with other divalent cations with intrinsic antibacterial and cytotoxic activity such as Zn2+ has not been explored yet. Thus, here, two commercially available sodium alginates were characterised and utilized in the synthesis of zinc alginate films with GO following the same chemical route reported for the calcium alginate/GO composites. The results of this study showed that zinc release, water sorption/diffusion and wettability depended significantly on the type of alginate utilized. Furthermore, Zn2+ and GO produced alginate films with increased water diffusion, wettability and opacity. However, neither the combination of GO with Zn2+ nor the use of different types of sodium alginates modified the antibacterial activity and cytotoxicity of the zinc alginates against these Gram-positive pathogens and human cells respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.