ArticleASAIO journal (American Society for Artificial Internal Organs : 1992)2020
In Vitro Durability and Stability Testing of a Novel Polymeric Transcatheter Aortic Valve.
Article in ASAIO journal (American Society for Artificial Internal Organs : 1992), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 28 citations in OpenAlex.
- Hematologic complications and design challenges in cardiovascular devices.Communications engineering · 2026Review
- Design and Fabrication of 3D-Printed Biomimetic Fiber-Reinforced Polymeric Aortic Valves for Improved Stress Distribution.Annals of biomedical engineering · 2026Article
- Innovation and Challenges in Materials for Transcatheter Aortic Valves.Journal of cardiovascular translational research · 2026Review
- From Polymer Structure to Valve Function: A Multiscale Evaluation of Polycarbonate Polyurethanes for Polymeric Mitral Valves.Annals of biomedical engineering · 2026Article
- Optimisation of Bioinspired Fibre Architectures for 3D-Printed Polymer Heart Valves via Melt Electrowriting (MEW) Using FE Modelling and Design of Experiments (FE-DOE).Biomimetics (Basel, Switzerland) · 2026Article
- Evolutions in Cardiovascular Implants-A Review of Past, Present, and Future.Micromachines · 2026Review
- Development of a Polymeric TAVR Device Tailored to Bicuspid Aortic Valve Patients Using In Silico Design Optimization and Evaluation.Annals of biomedical engineering · 2026Article
- Bioinspired functional materials for biomedical applications.Frontiers in bioengineering and biotechnology · 2026Review
- Effect of Initial Opening Morphology of Polymeric Valves on Hemodynamic Performance.Cardiovascular engineering and technology · 2025Article
- Polymeric Heart Valves: Do They Represent a Reliable Alternative to Current Prosthetic Devices?Polymers · 2025Review
- A chronological history of heart valve prostheses to offer perspectives of their limitations.Frontiers in bioengineering and biotechnology · 2025Review
- Innovation and Development in Polymer Heart Valves: A New Era of Transcatheter Aortic Valve Replacement.European cardiology · 2025Review
- Recent advancements in polymeric heart valves: From basic research to clinical trials.Materials today. Bio · 2024Review
- The Influence of Aortic Valve Disease on Coronary Hemodynamics: A Computational Model-Based Study.Bioengineering (Basel, Switzerland) · 2023Article
- Analysis of the Effect of Thickness on the Performance of Polymeric Heart Valves.Journal of functional biomaterials · 2023Article
- Flaw-insensitive fatigue resistance of chemically fixed collagenous soft tissues.Science advances · 2023Article
- Polymeric Heart Valves Will Displace Mechanical and Tissue Heart Valves: A New Era for the Medical Devices.International journal of molecular sciences · 2023Review
- Designing a Novel Asymmetric Transcatheter Aortic Valve for Stenotic Bicuspid Aortic Valves Using Patient-Specific Computational Modeling.Annals of biomedical engineering · 2023Article
- Transcatheter heart valve interventions for patients with rheumatic heart disease.Frontiers in cardiovascular medicine · 2023Review
- Polymeric prosthetic heart valves: A review of current technologies and future directions.Frontiers in cardiovascular medicine · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Transcatheter aortic valve replacement (TAVR) has emerged as an effective therapy for the unmet clinical need of inoperable patients with severe aortic stenosis (AS). Current clinically used tissue TAVR valves suffer from limited durability that hampers TAVR's rapid expansion to younger, lower risk patients. Polymeric TAVR valves optimized for hemodynamic performance, hemocompatibility, extended durability, and resistance to calcific degeneration offer a viable solution to this challenge. We present extensive in vitro durability and stability testing of a novel polymeric TAVR valve (PolyNova valve) using 1) accelerated wear testing (AWT, ISO 5840); 2) calcification susceptibility (in the AWT)-compared with clinically used tissue valves; and 3) extended crimping stability (valves crimped to 16 Fr for 8 days). Hydrodynamic testing was performed every 50M cycles. The valves were also evaluated visually for structural integrity and by scanning electron microscopy for evaluation of surface damage in the micro-scale. Calcium and phosphorus deposition was evaluated using micro-computed tomography (μCT) and inductive coupled plasma spectroscopy. The valves passed 400M cycles in the AWT without failure. The effective orifice area kept stable at 1.8 cm with a desired gradual decrease in transvalvular pressure gradient and regurgitation (10.4 mm Hg and 6.9%, respectively). Calcium and phosphorus deposition was significantly lower in the polymeric valve: down by a factor of 85 and 16, respectively-as compared to a tissue valve. Following the extended crimping testing, no tears nor surface damage were evident. The results of this study demonstrate the potential of a polymeric TAVR valve to be a viable alternative to tissue-based TAVR valves.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.