Observational studyRetina (Philadelphia, Pa.)2020
DETECTION OF CLINICALLY UNSUSPECTED RETINAL NEOVASCULARIZATION WITH WIDE-FIELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.
Observational study in Retina (Philadelphia, Pa.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 63 citations in OpenAlex.
- Tubercular retinal vasculitis in widefield optical coherence tomography angiography.American journal of ophthalmology case reports · 2026Article
- Ultra-widefield optical coherence tomography angiography in diabetic retinopathy: from retinal lesions to choroidal metrics.Frontiers in medicine · 2026Review
- Quantifying Choriocapillaris Flow Deficits in Diabetic Retinopathy Using Projection-Resolved OCT Angiography.Investigative ophthalmology & visual science · 2025Article
- Wide-field OCTA quantified peripheral nonperfusion areas predict the risk of subclinical neovascularization.Eye (London, England) · 2025Article
- Widefield OCT angiography.Progress in retinal and eye research · 2025Review
- Advances in OCT Angiography.Translational vision science & technology · 2025Review
- Visualizing features with wide-field volumetric OCT angiography.Optics express · 2024Article
- Detection of diabetic neovascularisation using single-capture 65°-widefield optical coherence tomography angiography.The British journal of ophthalmology · 2023Article
- Optical coherence tomography angiography in diabetic retinopathy.Progress in retinal and eye research · 2023Review
- OCT angiography and its retinal biomarkers [Invited].Biomedical optics express · 2023Review
- Utility of En Face OCT for the Detection of Clinically Unsuspected Retinal Neovascularization in Patients with Diabetic Retinopathy.Ophthalmology. Retina · 2023Observational
- Association Between Fluid Volume in Inner Nuclear Layer and Visual Acuity in Diabetic Macular Edema.American journal of ophthalmology · 2022Article
- Optical coherence tomography angiography for the detection and evaluation of ptic disc neovascularization: a retrospective, observational study.BMC ophthalmology · 2022Observational
- Optical coherence tomography.Nature reviews. Methods primers · 2022Article
- Interest of Widefield-Optical Coherence Tomography Angiography for Diagnosis and Follow-Up of Retinal Neovascularisation in Proliferative Diabetic Retinopathy.Journal of ophthalmology · 2022Article
- Optical Coherence Tomography Angiography in Diabetic Patients: A Systematic Review.Biomedicines · 2021Review
- Optical coherence tomography angiography in the management of diabetic retinopathy.Indian journal of ophthalmology · 2021Review
- An Open-Source Deep Learning Network for Reconstruction of High-Resolution OCT Angiograms of Retinal Intermediate and Deep Capillary Plexuses.Translational vision science & technology · 2021Article
- Comparison of Central Macular Fluid Volume With Central Subfield Thickness in Patients With Diabetic Macular Edema Using Optical Coherence Tomography Angiography.JAMA ophthalmology · 2021Observational
- Comparison of widefield swept-source optical coherence tomography angiography with ultra-widefield colour fundus photography and fluorescein angiography for detection of lesions in diabetic retinopathy.The British journal of ophthalmology · 2021Observational
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo evaluate wide-field optical coherence tomography angiography (OCTA) for detection of clinically unsuspected neovascularization (NV) in diabetic retinopathy (DR).
methodsThis prospective observational single-center study included adult patients with a clinical diagnosis of nonproliferative DR. Participants underwent a clinical examination, standard 7-field color photography, and OCTA with commercial and prototype swept-source devices. The wide-field OCTA was achieved by montaging five 6 × 10-mm scans from a prototype device into a 25 × 10-mm image and three 6 × 6-mm scans from a commercial device into a 15 × 6-mm image. A masked grader determined the retinopathy severity from color photographs. Two trained readers examined conventional and wide-field OCTA images for the presence of NV.
resultsOf 27 participants, photographic grading found 13 mild, 7 moderate, and 7 severe nonproliferative DR. Conventional 6 × 6-mm OCTA detected NV in 2 eyes (7%) and none with 3 × 3-mm scans. Both prototype and commercial wide-field OCTA detected NV in two additional eyes. The mean area of NV was 0.38 mm (range 0.17-0.54 mm). All eyes with OCTA-detected NV were photographically graded as severe nonproliferative DR.
conclusionWide-field OCTA can detect small NV not seen on clinical examination or color photographs and may improve the clinical evaluation of DR.
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Registered trials
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