Evidence map›Paper›PMID 30844765›Full record

ArticleAging2019

Curcumin inhibits liver metastasis of gastric cancer through reducing circulating tumor cells.

Xixi Gu, Qiqi Zhang, Wei Zhang, Liang Zhu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Xixi GuDepartment of Integrative Medicine, Zhongshan Hospital, University of Fudan, Shanghai 200032, China.
Qiqi ZhangDepartment of Integrative Medicine, Zhongshan Hospital, University of Fudan, Shanghai 200032, China.
Wei ZhangDepartment of Interventional Therapy, Zhongshan Hospital, University of Fudan, Shanghai 200032, China.
Liang ZhuDepartment of Interventional Therapy, Zhongshan Hospital, University of Fudan, Shanghai 200032, China.
Fudan University · CNZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary gastric cancer (PGC) is the fourth most common malignant human cancer and the second leading cause of death worldwide. The majority of the subjects of PGC is diagnosed at a late stage, resulting in poor prognosis and therapeutic outcome, largely attributable to dissemination of tumor cells into circulation as circulating tumor cells (CTCs) and their formation of distal tumor. Curcumin is an active ingredient from the rhizome of the plant Curcuma longa. Here, we assessed whether treatment with Curcumin may reduce the incidence of metastatic tumor formation in liver in mice carrying PGC. We found that Curcumin treatment significantly reduced the presence of CTCs and formation of liver tumor. Mechanistically, Curcumin reduced CXCR4 expression in PGCs in vitro and in vivo, and thus likely inhibited metastasis of PGC through suppression of stromal cell -derived factor-1/CXCR4 signaling. Thus, our study suggests that Curcumin may inhibit liver metastasis of PGC through reducing CTCs.

Indexed as

Neoplastic Cells, CirculatingAnimalsAntineoplastic AgentsCurcuminGene Expression Regulation, NeoplasticLiver NeoplasmsMiceMice, Inbred NODMice, TransgenicReceptors, CXCR4Stomach NeoplasmsAntineoplastic AgentsCurcuminCXCR4 protein, mouseReceptors, CXCR4Curcumin circulating tumor cells (CTCs)CXCR4primary gastric cancer (PGC)stromal cell -derived factor-1 (SDF-1)

Identifiers

PMID30844765
PMCPMC6428112
OpenAlexW2920887388

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.