Evidence map›Paper›PMID 30844535›Full record

ReviewPharmacological research2020

Pharmacological targeting of age-related changes in skeletal muscle tissue.

Aurel B Leuchtmann, Christoph Handschin

Abstract readReview
In one paragraph

Review in Pharmacological research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Skeletal muscle dysfunction with advancing age.Clinical science (London, England : 1979) · 2024
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Aurel B LeuchtmannBiozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056, Basel, Switzerland.
Christoph HandschinBiozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056, Basel, Switzerland. Electronic address: christoph.handschin@unibas.ch.
University of Basel · CH

Funding

European Research Council 616830Swiss National Science Foundation 156654
6 · The paper itself

Abstract

Sarcopenia, the age-related loss of skeletal muscle mass and function, increases the risk of developing chronic diseases in older individuals and is a strong predictor of disability and death. Because of the ongoing demographic transition, age-related muscle weakness is responsible for an alarming and increasing contribution to health care costs in Western countries. Exercise-based interventions are most successful in preventing the decline in skeletal muscle mass and in preserving or ameliorating functional capacities with increasing age. However, other treatment options are still scarce. In this review, we explore currently applied nutritional and pharmacological approaches to mitigate age-related muscle wasting, and discuss potential future therapeutic avenues.

Indexed as

AgingAnimalsHumansMuscle, SkeletalSarcopeniaAgingExercisemTORC1NutritionSarcopeniaSkeletal muscle

Identifiers

PMID30844535
PMCPMC7100900
OpenAlexW2920129658

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.