Evidence map›Paper›PMID 30844519›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2019

Pulmonary function and respiratory health after successful treatment of drug-resistant tuberculosis.

Sergo A Vashakidze, Jordan A Kempker, Nino A Jakobia, Shota G Gogishvili, Ketino A Nikolaishvili, Leila M Goginashvili, Matthew J Magee, Russell R Kempker

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06127641 (Rehabilitation of People With Post-tuberculosis Lung Disease), which is not on this map. Cited by 24 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 4 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06127641 narecruitingnot on this mapstarted 2023, after this paper: background citation

Rehabilitation of People With Post-tuberculosis Lung Disease

TypeinterventionalSponsorCentro Universitário Augusto MottaRan2023 to 2027Enrolled40ConditionsPulmonary TuberculosisArmsStandard care plus pulmonary rehabilitation, Standard Care
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Post-tuberculosis lung impairment: systematic review and meta-analysis of spirometry data from 14 621 people.European respiratory review : an official journal of the European Respiratory Society · 2023
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  18. Journal of personalized medicine · 2022
    Review
  19. Post-tuberculosis lung disease: a comparison of Brazilian, Italian, and Mexican cohorts.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Sergo A VashakidzeNational Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia. Electronic address: sergovashakidze@yahoo.com.
Jordan A KempkerDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Nino A JakobiaNational Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia.
Shota G GogishviliNational Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia.
Ketino A NikolaishviliNational Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia.
Leila M GoginashviliNational Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia.
Matthew J MageeGeorgia State University, School of Public Health, Atlanta, GA, USA.
Russell R KempkerDivision of Infectious Diseases Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
National Center for Tuberculosis and Lung Disease · GEEmory University · USGeorgia State University · US

Funding

Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Emory-Georgia TB Research Training ProgramD43TW007124 · FIC · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Nestani Tukvadze · 2004 to 2026
$4.6M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalKL2TR000455 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$2.9M
Intra Cavitary Pharmacokinetics and Drug Resistance in Pulmonary TuberculosisK23AI103044 · NIAID · EMORY UNIVERSITY · PI KEMPKER, RUSSELL RYAN · 2013 to 2017
$910k
A Geographic Approach to Determining the Preventable Causes of US Sepsis MortalityK08HS025240 · AHRQ · EMORY UNIVERSITY · PI KEMPKER, JORDAN ANTHONY · 2018 to 2020
$451k
A Clinical Pharmacology Study of a Novel Drug Regimen for Pre XDR and XDR TuberculosisR21AI122001 · NIAID · EMORY UNIVERSITY · PI KEMPKER, RUSSELL RYAN · 2016 to 2017
$369k
AHRQ HHS K08 HS025240FIC NIH HHS D43 TW007124NCATS NIH HHS KL2 TR000455NCATS NIH HHS UL1 TR000454NHLBI NIH HHS L30 HL124529NIAID NIH HHS K23 AI103044NIAID NIH HHS R21 AI122001
6 · The paper itself

Abstract

backgroundPost-treatment morbidity among subjects with drug-resistant tuberculosis (DR-TB) is unclear.

methodsThis was a cross-sectional study of patients from Tbilisi, Georgia with cavitary DR-TB and an outcome of cure. Participants had a chest X-ray (CXR), St. George Respiratory Quality (SGRQ) survey, and pulmonary function tests (PFTs) performed. Correlations between SGRQ and PFT results and factors associated with pulmonary impairment were examined.

resultsAmong 58 subjects (median age 31 years), 40% used tobacco, 59% had prior TB, and 47% underwent adjunctive surgical resection. The median follow-up time was 41 months. Follow-up CXR revealed fibrosis in 30 subjects (52%) and bronchiectasis in seven (12%). The median forced expiratory volume (FEV

conclusionsA high proportion of DR-TB subjects had residual pulmonary impairment, particularly with recurrent TB and severe radiological disease. The association of surgical resection with improved lung function deserves further study. PFTs and SGRQ may both be useful to evaluate lung health.

Indexed as

AdultBronchiectasisCohort StudiesCross-Sectional StudiesFemaleForced Expiratory VolumeGeorgiaHumansLungMaleMiddle AgedPulmonary FibrosisRadiographyRespiratory Function TestsRetrospective StudiesSurveys and QuestionnairesImpairmentLung healthPulmonary functionSt. George Respiratory Quality surveySurgeryTuberculosis

Identifiers

PMID30844519
PMCPMC6528816
OpenAlexW2920664581

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.