ArticleJournal of the American Academy of Child and Adolescent Psychiatry2020
Telomere Length and Psychopathology: Specificity and Direction of Effects Within the Bucharest Early Intervention Project.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00747396 (The Bucharest Early Intervention Project), which is not on this map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Bucharest Early Intervention Project: Effects of Early Psychosocial Deprivation on Mental Health in Adolescence
Who cites it
12 citing papers in PubMed.
- Telomere trajectories from early adolescence to adulthood following early institutionalization: Protective effects of foster care in the Bucharest Early Intervention Project.Psychoneuroendocrinology · 2026Trial
- Practitioner Review: Infant mental health meets cell and molecular biology - a look to the future.Journal of child psychology and psychiatry, and allied disciplines · 2026Review
- Telomere Length and Emotional and Behavioral Problems in Children from the Prospective Birth Cohort INfancia y Medio Ambiente (INMA) Study.Children (Basel, Switzerland) · 2025Article
- Article
- Examining the Biological Impacts of Parent-Child Relationship Dynamics on Preschool-Aged Children who have Experienced Adversity.Developmental psychobiology · 2024Observational
- The Social Environment Matters for Telomere Length and Internalizing Problems During Adolescence.Journal of youth and adolescence · 2024Article
- Developmental Correlates of Accelerated Molar Eruption in Early Childhood.Biological psychiatry global open science · 2023Article
- Associations of depression and anxiety and adolescent telomere length.Psychoneuroendocrinology · 2023Article
- What was learned from studying the effects of early institutional deprivation.Pharmacology, biochemistry, and behavior · 2021Review
- Mechanisms linking childhood trauma exposure and psychopathology: a transdiagnostic model of risk and resilience.BMC medicine · 2020Article
- Adverse Childhood Experiences: Implications for Offspring Telomere Length and Psychopathology.The American journal of psychiatry · 2020Article
- Telomere Maintenance in Pediatric Cancer.International journal of molecular sciences · 2019Review
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5 authors.
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Abstract
objectiveTelomere length (TL) has been linked to several psychiatric conditions in children and adults. Telomere shortening is accelerated by early adversity, including maltreatment and psychosocial deprivation. These experiences also increase the risk of psychopathology in many domains. Two fundamental issues remain unresolved. The first concerns the specificity of the relations between TL and different dimensions of psychopathology; and the second relates to the direction of association between TL and psychopathology.
methodThis study addressed these shortcomings in a 2-fold manner. First, the association between TL and statistically independent general, internalizing, and externalizing psychopathology factors was examined to determine the specificity of this relation. Second, a 2-wave longitudinal cross-lagged model was used to explicitly examine the direction of the relation between TL and each psychopathology factor. Data were drawn from the Bucharest Early Intervention Project, a longitudinal study exploring the impact of severe psychosocial deprivation on child health and development (N = 195). At 8 to 10 and 12 to 14 years of age, buccal DNA was collected and teachers and/or caregivers reported on different domains of psychopathology.
resultsLongitudinal path analyses showed that shorter TL was specifically associated with higher internalizing psychopathology at 8 to 10 years of age. In contrast, at 12 to 14 years, shorter TL was associated with higher general psychopathology. Most telling, internalizing psychopathology at 8 to 10 years predicted shorter TL at 12 to 14 years, with no reciprocal effects.
conclusionResults suggest that telomere erosion could be a consequence of distress-related psychopathology rather than a selection mechanism for later psychiatric problems. CLINICAL TRIAL REGISTRATION INFORMATION: The Bucharest Early Intervention Project; https://clinicaltrials.gov/; NCT00747396.
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