Evidence map›Paper›PMID 30844410›Full record

ReviewAdvanced drug delivery reviews2019

Leveraging the interplay of nanotechnology and neuroscience: Designing new avenues for treating central nervous system disorders.

Elizabeth S Smith, Joshua E Porterfield, Rangaramanujam M Kannan

Abstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
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  7. Review
  8. Review
  9. Dendrimer-2PMPA Delays Muscle Function Loss and Denervation in a Murine Model of Amyotrophic Lateral Sclerosis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Article
  10. Article
  11. Article
  12. Review
  13. Review
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Elizabeth S SmithCenter for Nanomedicine, Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Joshua E PorterfieldCenter for Nanomedicine, Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Rangaramanujam M KannanCenter for Nanomedicine, Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA; Hugo W. Moser Research Institute at Kennedy Krieger, Inc., Baltimore, MD 21205, USA; Kennedy Krieger Institute, Johns Hopkins University for Cerebral Palsy Research Excellence, Baltimore, MD 21218, USA. Electronic address: krangar1@jhmi.edu.

Funding

Targeting glutamate carboxypeptidase in perinatal brain injuryR01NS093416 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Sujatha Kannan, Kannan Rangaramanujam · 2016 to 2026
$4.8M
NINDS CREATE DISCOVERY: Development of dendrimer-N-acetylcysteine for the treatment of neonatal brain injuryU01NS103882 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KANNAN, SUJATHA, RANGARAMANUJAM, KANNAN · 2018 to 2021
$2.8M
Dendrimer-conjugated nSMase2 inhibitor as a novel therapeutic approach for Alzheimer's DiseaseR01AG063831 · NIA · JOHNS HOPKINS UNIVERSITY · PI RAIS, RANA, RANGARAMANUJAM, KANNAN · 2020 to 2024
$2.3M
Targeted Therapies for Rett SyndromeR01NS113140 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KANNAN, SUJATHA · 2019 to 2023
$2.0M
Postnatal combination therapy for cerebral palsyR01HD076901 · NICHD · JOHNS HOPKINS UNIVERSITY · PI RANGARAMANUJAM, KANNAN · 2014 to 2018
$1.7M
Systemic nanotherapies for ocular inflammation and choroidal neovascularization.R01EY025304 · NEI · JOHNS HOPKINS UNIVERSITY · PI RANGARAMANUJAM, KANNAN · 2015 to 2018
$1.6M
Nanotherapies for the treatment of neurodevelopmental disorders.R01EB018306 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI RANGARAMANUJAM, KANNAN · 2014 to 2017
$1.5M
NEI NIH HHS R01 EY025304NIA NIH HHS R01 AG063831NIBIB NIH HHS R01 EB018306NICHD NIH HHS R01 HD076901NINDS NIH HHS R01 NS093416NINDS NIH HHS R01 NS113140NINDS NIH HHS U01 NS103882
6 · The paper itself

Abstract

Nanotechnology has the potential to open many novel diagnostic and treatment avenues for disorders of the central nervous system (CNS). In this review, we discuss recent developments in the applications of nanotechnology in CNS therapies, diagnosis and biology. Novel approaches for the diagnosis and treatment of neuroinflammation, brain dysfunction, psychiatric conditions, brain cancer, and nerve injury provide insights into the potential of nanomedicine. We also highlight nanotechnology-enabled neuroscience techniques such as electrophysiology and intracellular sampling to improve our understanding of the brain and its components. With nanotechnology integrally involved in the advancement of basic neuroscience and the development of novel treatments, combined diagnostic and therapeutic applications have begun to emerge. Nanotheranostics for the brain, able to achieve single-cell resolution, will hasten the rate in which we can diagnose, monitor, and treat diseases. Taken together, the recent advances highlighted in this review demonstrate the prospect for significant improvements to clinical diagnosis and treatment of a vast array of neurological diseases. However, it is apparent that a strong dialogue between the nanoscience and neuroscience communities will be critical for the development of successful nanotherapeutics that move to the clinic, benefit patients, and address unmet needs in CNS disorders.

Indexed as

NanotechnologyNeurosciencesCentral Nervous System DiseasesDrug Delivery SystemsHumansNanoparticlesNeuroprotective AgentsNeuroprotective AgentsCentral nervous systemGlioblastomaNanomedicineNerve repairNeurodegenerationNeuroinflammationPsychiatric disordersTheranosticsTranslational medicine

Identifiers

PMID30844410
PMCPMC7043366

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.