ReviewNeuron2019
Composite Pain Biomarker Signatures for Objective Assessment and Effective Treatment.
Review in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 120 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Understanding Opioid Use Before and After Surgery in Norway: A Prospective Multicenter Study and Randomized Double-blind Controlled Study
Diode Laser as a Biomarker for Neuropathic Pain of Peripheral Origin.
Unveiling Physiological and Psychosocial Pain Components with an Artificial Intelligence Based Telemonitoring Tool (pAIn-sense)
Multi-modal Smart Band-Aid for AI-based Quantification of Pain
Who cites it
120 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Recommendations for the Neurophysiological Assessment of Conditioned Pain Modulation: A Systematic Review of Nociceptive Blink Reflex and Nociceptive Withdrawal Reflex Protocols.European journal of pain (London, England) · 2025Pooled it
- Pharmacological Probes to Validate Biomarkers for Analgesic Drug Development.International journal of molecular sciences · 2022Pooled it
- Effect of sleep loss on pain-New conceptual and mechanistic avenues.Frontiers in neuroscience · 2022Pooled it
- Variability and effect sizes of intracranial current source density estimations during pain: Systematic review, experimental findings, and future perspectives.Human brain mapping · 2021Pooled it
- Influence of Transcutaneous Electrical Nerve Stimulation (TENS) on Pressure Pain Thresholds and Conditioned Pain Modulation in a Randomized Controlled Trial in Women With Fibromyalgia.The journal of pain · 2024Trial
- Prediction of Differential Pharmacologic Response in Chronic Pain Using Functional Neuroimaging Biomarkers and a Support Vector Machine Algorithm: An Exploratory Study.Arthritis & rheumatology (Hoboken, N.J.) · 2021Trial
- Electroencephalography research in neuropathic pain (Review).Molecular medicine reports · 2026Review
- Longitudinal stability of data-driven fibromyalgia phenotypes across repeated clinical assessments.Pain reports · 2026Article
- Effects ofPain reports · 2026Article
- Beyond the jaw: vocal, oropharyngeal and cognitive-linguistic biomarkers for precision pain phenotyping in TMD.Journal of oral & facial pain and headache · 2026Review
- Glutamatergic Projection from the Ventrolateral Periaqueductal Gray to the Parafascicular Nucleus of the Thalamus Contributes to the Modulation of Neuropathic Pain in Mice.Neurochemical research · 2026Article
- From Association to Prediction: Translational Barriers in Pain Biomarker Research.Journal of personalized medicine · 2026Article
- Towards a holistic understanding of pain in the biomarker age.Nature neuroscience · 2026Article
- Astrocytic ion channel Kir4.1 deficit underlies chronic pain.Neural regeneration research · 2026Article
- Sensory and cortical biomarkers unveil pain modulation mechanisms induced by targeted multisensory neurostimulation.Journal of neuroengineering and rehabilitation · 2026Article
- Neuroinflammatory Biomarkers in Chronic Low Back Pain: Mechanisms, Clinical Evidence, and Translational Challenges.Biomedicines · 2026Review
- From Amputation to Persistent Pain: A Review of Molecular and Cellular Processes in Phantom Limb Pain.International journal of molecular sciences · 2026Review
- Exosomes: Roles and Therapeutic Potential in Pain.Biomedicines · 2026Review
- Article
- Peripheral Blood Cells and Clinical Profiles as Biomarkers for Pain Detection in Palliative Care Patients.Biomedicines · 2026Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Pain is a subjective sensory experience that can, mostly, be reported but cannot be directly measured or quantified. Nevertheless, a suite of biomarkers related to mechanisms, neural activity, and susceptibility offer the possibility-especially when used in combination-to produce objective pain-related indicators with the specificity and sensitivity required for diagnosis and for evaluation of risk of developing pain and of analgesic efficacy. Such composite biomarkers will also provide improved understanding of pain pathophysiology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.