Evidence map›Paper›PMID 30844079›Full record

ArticleActa psychiatrica Scandinavica2019

Undiagnosed cardiovascular disease prior to cardiovascular death in individuals with severe mental illness.

I H Heiberg, B K Jacobsen, L Balteskard, J G Bramness, Ø Naess, E Ystrom, T Reichborn-Kjennerud, C M Hultman, R Nesvåg, A Høye

Abstract read
In one paragraph

Article in Acta psychiatrica Scandinavica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  10. Self-harming behavior linked to earlier onset of cardiovascular disease in severe mental disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2025
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  20. Making meaning of multimorbidity and severe mental illness: A viewpoint.The Australian and New Zealand journal of psychiatry · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

I H HeibergCenter for Clinical Documentation and Evaluation (SKDE), Tromsø, Norway.ORCID 0000-0001-7635-5826
B K JacobsenCenter for Clinical Documentation and Evaluation (SKDE), Tromsø, Norway.
L BalteskardCenter for Clinical Documentation and Evaluation (SKDE), Tromsø, Norway.
J G BramnessNorwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health Disorders, Innlandet Hospital Trust, Hamar, Norway.
Ø NaessInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
E YstromDepartment of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.
T Reichborn-KjennerudInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
C M HultmanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
R NesvågDepartment of Clinical Medicine, UiT - The Arctic University of Norway, Tromsø, Norway.
A HøyeCenter for Clinical Documentation and Evaluation (SKDE), Tromsø, Norway.

Funding

Helse Nord RHF PFP1236-15
6 · The paper itself

Abstract

objectiveTo examine whether individuals with schizophrenia (SCZ) or bipolar disorder (BD) had equal likelihood of not being diagnosed with cardiovascular disease (CVD) prior to cardiovascular death, compared to individuals without SCZ or BD.

methodsMultivariate logistic regression analysis including nationwide data of 72 451 cardiovascular deaths in the years 2011-2016. Of these, 814 had a SCZ diagnosis and 673 a BD diagnosis in primary or specialist health care.

resultsIndividuals with SCZ were 66% more likely (OR: 1.66; 95% CI: 1.39-1.98), women with BD were 38% more likely (adjusted OR: 1.38; 95% CI: 1.04-1.82), and men with BD were equally likely (OR: 0.88, 95% CI: 0.63-1.24) not to be diagnosed with CVD prior to cardiovascular death, compared to individuals without SMI. Almost all (98%) individuals with SMI and undiagnosed CVD had visited primary or specialized somatic health care prior to death, compared to 88% among the other individuals who died of CVD.

conclusionIndividuals with SCZ and women with BD are more likely to die due to undiagnosed CVD, despite increased risk of CVD and many contacts with primary and specialized somatic care. Strengthened efforts to prevent, recognize, and treat CVD in individuals with SMI from young age are needed.

Indexed as

Severity of Illness IndexAdultBipolar DisorderCardiovascular DiseasesFemaleFollow-Up StudiesHumansMaleMiddle AgedRisk AssessmentSchizophreniaYoung Adultadultbipolar disordercardiovascular diseasesdeathdelayed diagnosisschizophreniatreatment delay

Identifiers

PMID30844079
PMCPMC6619029

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.