ArticleThe Journal of clinical endocrinology and metabolism2019
Distinctive Reproductive Phenotypes in Peripubertal Girls at Risk for Polycystic Ovary Syndrome.
Article in The Journal of clinical endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical Utility of Anti-Mullerian Hormone in Pediatrics.The Journal of clinical endocrinology and metabolism · 2022Pooled it
- The Ontogeny of Distinct Reproductive Phenotypes in Girls at Risk for PCOS During the Postmenarchal Transition.The Journal of clinical endocrinology and metabolism · 2026Article
- POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: Genetics of polycystic ovary syndrome (PCOS).Reproduction (Cambridge, England) · 2025Review
- Nutritional and herbal interventions for polycystic ovary syndrome (PCOS): a comprehensive review of dietary approaches, macronutrient impact, and herbal medicine in management.Journal of health, population, and nutrition · 2025Review
- Bile acids: potential links to overweight/obesity and androgen levels in pubertal girls.Frontiers in endocrinology · 2025Article
- Serum kisspeptin as a promising biomarker for PCOS: a mini review of current evidence and future prospects.Clinical diabetes and endocrinology · 2024Review
- Beyond defence: Immune architects of ovarian health and disease.Seminars in immunopathology · 2024Review
- Pubertal Girls With Overweight/Obesity Have Higher Androgen Levels-Can Metabolomics Tell us Why?The Journal of clinical endocrinology and metabolism · 2024Article
- High Fat Diet and Polycystic Ovary Syndrome (PCOS) in Adolescence: An Overview of Nutritional Strategies.Nutrients · 2024Review
- Anti-Müllerian Hormone: A Molecular Key to Unlocking Polycystic Ovary Syndrome?Seminars in reproductive medicine · 2024Review
- Sports and Weight Control in Children.Cureus · 2024Review
- The Effect on Inflammation of Adherence to the Mediterranean Diet in Polycystic Ovary Syndrome.Current nutrition reports · 2023Review
- Deconstructing a Syndrome: Genomic Insights Into PCOS Causal Mechanisms and Classification.Endocrine reviews · 2022Article
- Update on Animal Models of Polycystic Ovary Syndrome.Endocrinology · 2022Article
- The role of gonadotropin-releasing hormone neurons in polycystic ovary syndrome.Journal of neuroendocrinology · 2022Review
- Consequences of hyperandrogenemia during pregnancy in female offspring: attenuated response to angiotensin II.Journal of hypertension · 2022Article
- Cardiovascular disease risk in offspring of polycystic ovary syndrome.Frontiers in endocrinology · 2022Review
- Cardiometabolic consequences of maternal hyperandrogenemia in male offspring.Physiological reports · 2021Article
- Review
- Longitudinal Investigation of Pubertal Milestones and Hormones as a Function of Body Fat in Girls.The Journal of clinical endocrinology and metabolism · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
contextIncreased testosterone (T) levels are a cardinal feature of polycystic ovary syndrome (PCOS). Female relatives of affected women, including premenarchal daughters, have elevated T levels supporting a genetic susceptibility to this phenotype. Girls with obesity (OB-g) also have increased T levels throughout puberty, which may indicate risk for PCOS.
objectiveWe tested the hypothesis that premenarchal daughters of women affected with PCOS (PCOS-d) have distinctive phenotypic features compared with OB-g. DESIGN, SETTING, AND
participantsForty-eight PCOS-d, 30 OB-g, and 22 normal weight (NW-g) premenarchal girls were studied. Mothers of OB-g and NW-g had no evidence for PCOS.
main outcome measuresReproductive hormones were measured.
resultsBody mass index differed by design, was highest in OB-g, followed by PCOS-d (P > 0.001). PCOS-d and OB-g had similar increases in free T levels compared with NW-g (PCOS-d vs NW-g, P = 0.01; OB-g vs NW-g, P = 0.0001). Sex hormone binding globulin levels were lowest in OB-g and lower in PCOS-d than in NW-g (PCOS-d vs NW-g, P = 0.005; OB-g vs NW-g, P < 0.0001; PCOS-d vs OB-g, P < 0.0001). Anti-Müllerian hormone (AMH) levels in PCOS-d were significantly increased compared with OB-g, who tended to have lower AMH levels than NW-g (PCOS-d vs OB-g, P < 0.0001; PCOS-d vs NW-g, P = 0.10).
conclusionsDespite similarly elevated free T levels, PCOS-d had increased AMH levels compared with OB-g. This finding suggests that OB-g lack alterations in ovarian folliculogenesis, a key reproductive feature of PCOS. Causal mechanisms may differ in PCOS-d or OB-g, or elevated T in OB-g may not be an early marker for PCOS.
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Registered trials
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