ReviewRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)2019
Pharmacokinetics of antidepressants in patients undergoing hemodialysis: a narrative literature review.
Review in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Mental Health Disorders in End-Stage Kidney Disease: A Narrative Review of Clinical Considerations for Integrated Management.Hemodialysis international. International Symposium on Home Hemodialysis · 2026Review
- Treating depression in dialysis patients: pharmacological and non-pharmacological approaches.Clinical kidney journal · 2026Review
- Clinical and Psychological Impact of COVID-19 on Maintenance Hemodialysis Patients: Hospitalization Burden, De Novo Anxiolytic Use, and Long-Term Survival.Medicina (Kaunas, Lithuania) · 2026Article
- Therapeutic Drug Monitoring for Individualized Antidepressant Treatment.Drug design, development and therapy · 2025Article
- Pharmacological and psychological treatment of depression and anxiety among hemodialyzed patients - a review.Postepy psychiatrii neurologii · 2024Review
- Choosing the right chronic medication for hemodialysis patients. A short ABC for the dialysis nephrologist.Journal of nephrology · 2023Review
- Polypharmacy and Mental Health Issues in the Senior Hemodialysis Patient.Frontiers in psychiatry · 2022Review
- Mental Health Care for Adults Treated With Dialysis in Canada: A Scoping Review.Canadian journal of kidney health and disease · 2022Article
- Use of Sertraline in Hemodialysis Patients.Medicina (Kaunas, Lithuania) · 2021Review
- Multifaceted Sexual Dysfunction in Dialyzing Men and Women: Pathophysiology, Diagnostics, and Therapeutics.Life (Basel, Switzerland) · 2021Review
- A Narrative Review of Management Strategies for Common Symptoms in Advanced CKD.Kidney international reports · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We conducted a narrative literature review on studies that specifically addressed the pharmacokinetics of antidepressants in patients on hemodialysis. The search included the MEDLINE, LILACS, and Web of Knowledge databases and combined Medical Subject Headings and free-text search terms for chronic kidney disease, end-stage renal disease, renal replacement therapy, depression, and antidepressants; it was limited to studies conducted in humans, with no language or time constraints. The search yielded 212 studies. After screening titles and abstracts, 32 studies were read in full and 11 ultimately met the inclusion criteria and were included in the review. Most of the studies showed no difference in the pharmacokinetics of antidepressant drugs between patients with normal renal function and patients undergoing hemodialysis. However, studies with fluvoxamine and amitriptyline showed that variations in albumin levels might affect serum concentrations of these agents. The included studies have several limitations, and there are many obstacles to the adequate treatment of depression in patients undergoing hemodialysis. Further studies on this topic are needed to support proper treatment of these patients, improving their quality of life and reducing mortality.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.