ArticleJCI insight2019
Propionibacterium acnes-induced immunopathology correlates with health and disease association.
Article in JCI insight, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- Decoding Sebaceous Gland Biology Through Experimental Models: Progress, Limitations, and Future Directions.Cells · 2026Review
- Microbial Hyaluronidases: From Obscure Virulence Factors to Promising Therapeutic Targets.Biomolecules · 2026Review
- Dissolvable silk microneedles delivering minocycline-loaded ZIF-8 nanoparticles for targeted modulation of sebocyte metabolism and improved acne therapy.Journal of nanobiotechnology · 2026Article
- Efficacy and Safety of Human Skin Microbiome-Derived Strains as Topical Treatment for Acne: An In Vitro and In Vivo Study.Journal of Korean medical science · 2025Article
- Immune Activation and Glycolytic Responses to Cutibacterium acnes Cell Wall Polysaccharides.The Journal of investigative dermatology · 2025Article
- Zinc-EnrichedNutrients · 2025Article
- Assessing Anti-Acne PotentialsCurrent drug targets · 2025Review
- Comparative transcriptome analysis of acne vulgaris, rosacea, and hidradenitis suppurativa supports high-dose dietary zinc as a therapeutic agent.Experimental dermatology · 2024Article
- DistinctFrontiers in microbiomes · 2024Article
- Functional divergence of a bacterial enzyme promotes healthy or acneic skin.Nature communications · 2023Article
- Comparative Transcriptome Analysis of Acne vulgaris, Rosacea, and Hidradenitis Suppurativa Supports High Dose Dietary Zinc as a Therapeutic Agent.medRxiv : the preprint server for health sciences · 2023Article
- The updates and implications of cutaneous microbiota in acne.Cell & bioscience · 2023Review
- Biological Evaluation of the Antibacterial Retinoid CD437 in Cutibacterium acnes Infection.Antimicrobial agents and chemotherapy · 2023Article
- Topical phage therapy in a mouse model of Cutibacterium acnes-induced acne-like lesions.Nature communications · 2023Article
- Network Pharmacology and Experimental Validation to Explore the Molecular Mechanisms of Compound Huangbai Liquid for the Treatment of Acne.Drug design, development and therapy · 2023Article
- Characterization of aInternational journal of molecular sciences · 2022Article
- Prospective study of oral microbiome and gastric cancer risk among Asian, African American and European American populations.International journal of cancer · 2022Article
- The defense response of Caenorhabditis elegans to Cutibacterium acnes SK137 via the TIR-1-p38 MAPK signaling pathway.Bioscience, biotechnology, and biochemistry · 2022Article
- Antimicrobial production by perifollicular dermal preadipocytes is essential to the pathophysiology of acne.Science translational medicine · 2022Article
- Analysis of drug efficacy for inflammatory skin on an organ-chip system.Frontiers in bioengineering and biotechnology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Genomic studies revealed the existence of health- and acne-associated P. acnes strains and suggested novel approaches for broadening understanding of acne vulgaris. However, clinical association of P. acnes with disease or health has yet to be corroborated experimentally. Current animal models of acne do not closely mimic human disease and have unclear translational value. We have developed a murine model of acne by combining P. acnes inoculation with topical application of a synthetic human sebum. We showed that human sebum promoted persistence of intradermally injected P. acnes with little loss of viability after 1 week and permitted use of more physiologic inoculums. Application of acne-associated P. acnes RT4/5 strains led to development of moderate to severe skin pathology compared with application of health-associated type II P. acnes strains (RT2/6). RT4/5 P. acnes strains uniformly induced higher levels of KC (IL-8), IL-1α, IL-1β, and IL-6 in vitro and in vivo compared with type II P. acnes strains. Overall, our data provide immunopathologic corroboration of health and disease association of clinical P. acnes strains and inform on a platform to query putative virulence factors uncovered by genomic studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.