Evidence map›Paper›PMID 30843756›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2020

Axonal damage in spinal cord is associated with gray matter atrophy in sensorimotor cortex in experimental autoimmune encephalomyelitis.

Cassandra E Meyer, Josephine L Gao, James Ying-Jie Cheng, Mandavi R Oberoi, Hadley Johnsonbaugh, Stefano Lepore, Florian Kurth, Mackenzie J Thurston, Noriko Itoh, Kevin R Patel and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Neuroprotection in Cerebral Cortex Induced by the Pregnancy Hormone Estriol.Laboratory investigation; a journal of technical methods and pathology · 2023
    Article
  6. Article
  7. The X factor in neurodegeneration.The Journal of experimental medicine · 2022
    Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Cassandra E MeyerAhmanson-Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA/ UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Josephine L GaoAhmanson-Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA/ UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
James Ying-Jie ChengAhmanson-Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA/ UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Mandavi R OberoiAhmanson-Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA/ UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Hadley JohnsonbaughAhmanson-Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA/ UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Stefano LeporeAhmanson-Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA/ UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Florian KurthAhmanson-Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA/ UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Mackenzie J ThurstonAhmanson-Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA/ UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Noriko ItohUCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Kevin R PatelUCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Rhonda R VoskuhlUCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Allan MacKenzie-GrahamAhmanson-Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA/ UCLA Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Brain Mapping Foundation · US

Funding

AN INFORMATICS FACILITY FOR NEUROIMAGINGC06RR015431 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TOGA, ARTHUR W · 2000 to 2000
$2.0M
Bringing CLARITY to EAER01NS086981 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MACKENZIE-GRAHAM, ALLAN JAMES · 2015 to 2018
$1.3M
High Capacity Storage System for Computational BiologyS10OD011939 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WOODS, ROGER P · 2012 to 2012
$598k
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR012169 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAZZIOTTA, JOHN C · 1996 to 1997
–
NCRR NIH HHS C06 RR012169NCRR NIH HHS C06 RR015431NIH HHS S10 OD011939NINDS NIH HHS R01 NS086981
6 · The paper itself

Abstract

backgroundGray matter (GM) atrophy in brain is one of the best predictors of long-term disability in multiple sclerosis (MS), and recent findings have revealed that localized GM atrophy is associated with clinical disabilities. GM atrophy associated with each disability mapped to a distinct brain region, revealing a disability-specific atlas (DSA) of GM loss.

objectiveTo uncover the mechanisms underlying the development of localized GM atrophy.

methodsWe used voxel-based morphometry (VBM) to evaluate localized GM atrophy and Clear Lipid-exchanged Acrylamide-hybridized Rigid Imaging-compatible Tissue-hYdrogel (CLARITY) to evaluate specific pathologies in mice with experimental autoimmune encephalomyelitis (EAE).

resultsWe observed extensive GM atrophy throughout the cerebral cortex, with additional foci in the thalamus and caudoputamen, in mice with EAE compared to normal controls. Next, we generated pathology-specific atlases (PSAs), voxelwise mappings of the correlation between specific pathologies and localized GM atrophy. Interestingly, axonal damage (end-bulbs and ovoids) in the spinal cord strongly correlated with GM atrophy in the sensorimotor cortex of the brain.

conclusionThe combination of VBM with CLARITY in EAE can localize GM atrophy in brain that is associated with a specific pathology in spinal cord, revealing a PSA of GM loss.

Indexed as

AnimalsAtrophyEncephalomyelitis, Autoimmune, ExperimentalFemaleGray MatterHydrogelsMagnetic Resonance ImagingMiceMice, Inbred C57BLMultiple SclerosisSensorimotor CortexSpinal CordHydrogelsaxonal lossCLARITYEAEMSneurodegenerationVoxel-based morphometry

Identifiers

PMID30843756
PMCPMC6957766
OpenAlexW2921924838

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.