ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2019
The platelet-derived growth factor receptor alpha promoter-directed expression of cre recombinase in mouse placenta.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
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- Requirement of Pdgfrα+ cells for calvarial bone repair.Stem cells translational medicine · 2024Article
- Conditionally mutant animal model for investigating the invasive trophoblast cell lineage.Development (Cambridge, England) · 2024Article
- The RBPMSiScience · 2023Article
- The Past, Present, and Future of Genetically Engineered Mouse Models for Skeletal Biology.Biomolecules · 2023Review
- Article
- Mouse In Vivo Placental Targeted CRISPR Manipulation.Journal of visualized experiments : JoVE · 2023Article
- Wnt-Dependent Activation of ERK Mediates Repression of Chondrocyte Fate during Calvarial Development.Journal of developmental biology · 2021Article
- Adiponectin Promotes Maternal β-Cell Expansion Through Placental Lactogen Expression.Diabetes · 2021Article
- Lineage Contribution of PDGFRBioMed research international · 2021Article
- The platelet-derived growth factor receptor alpha promoter-directed expression of cre recombinase in mouse placenta.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNumerous pathologies of pregnancy originate from placental dysfunction. It is essential to understand the functions of key genes in the placenta in order to discern the etiology of placental pathologies. A paucity of animal models that allow conditional and inducible expression of a target gene in the placenta is a major limitation for studying placental development and function.
resultsTo study the platelet-derived growth factor receptor alpha (PDGFRα)-directed and tamoxifen-induced Cre recombinase expression in the placenta, PDGFRα-CreER mice were crossed with mT/mG dual-fluorescent reporter mice. The expression of endogenous membrane-localized enhanced green fluorescent protein (mEGFP) and/or dTomato in the placenta was examined to identify PDGFRα promoter-directed Cre expression. Pregnant PDGFRα-CreER;mT/mG mice were treated with tamoxifen at various gestational ages. Upon tamoxifen treatment, reporter protein mEGFP was observed in the junctional zone (JZ) and chorionic plate (CP). Furthermore, a single dose of tamoxifen was sufficient to induce the recombination.
conclusionsPDGFRα-CreER expression is restricted to the JZ and CP of mouse placentas. PDGFRα-CreER mice provide a useful tool to conditionally knock out or overexpress a target gene in these regions of the mouse placenta.
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