Evidence map›Paper›PMID 30843447›Full record

ArticleThe Journal of international medical research2019

Association of body mass and systemic immune-inflammation indices with endocrine therapy resistance in luminal breast cancers.

Qing-Xia Li, Dong-Jian Shi, Li-Xia Zhang, Dong-Miao Wang, Jing Zhao, Tao Wang, Xin-Na Deng, Xiao-Yan Fan

Open access · goldAbstract read
In one paragraph

Article in The Journal of international medical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Qing-Xia Li1 The Fourth Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei, P.R. China.ORCID https://orcid.org/0000-0001-9934-7837
Dong-Jian Shi2 Intensive Care Unit, Affiliated Hospital of Chengde Medical University, Chengde, Hebei, P.R. China.
Li-Xia Zhang1 The Fourth Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei, P.R. China.
Dong-Miao Wang1 The Fourth Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei, P.R. China.
Jing Zhao3 The First Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei, P.R. China.
Tao Wang4 Department of Science and Education, Hebei General Hospital, Shijiazhuang, Hebei, P.R. China.
Xin-Na Deng1 The Fourth Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei, P.R. China.
Xiao-Yan Fan1 The Fourth Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei, P.R. China.
Hebei General Hospital · CNChengde Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore correlations between body mass index (BMI), preoperative systemic immune-inflammation index (SII) and endocrine therapy resistance, and evaluate BMI and SII as predictors of resistance, in patients with luminal breast cancer.

methodsThis retrospective study included patients with luminal breast cancer who underwent endocrine therapy at Hebei General Hospital. Relationships between BMI and SII subgroups, and clinicopathological parameters were analysed using χ

resultsOut of 161 patients, those with normal BMI and low SII had significantly lower endocrine resistance rates versus those with high BMI and SII, and BMI was significantly positively correlated with SII. High BMI or SII was associated with significantly lower disease-free survival rates. Hazard ratios for disease progression risk were 6.036, 3.508 and 1.733, for SII, BMI and TNM stage, respectively.

conclusionIn patients with luminal breast cancer, high BMI (>23 kg/m

Indexed as

Body WeightDrug Resistance, NeoplasmBody Mass IndexBreast NeoplasmsFemaleHormonesHumansInflammationMiddle AgedMultivariate AnalysisProportional Hazards ModelsROC CurveHormonesbody mass index (BMI)Breast cancerendocrine resistanceluminal subtypesystemic immune-inflammation index (SII)

Identifiers

PMID30843447
PMCPMC6567779
OpenAlexW2921188107

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.