ArticleJournal of clinical laboratory analysis2019
IDO and intra-tumoral neutrophils were independent prognostic factors for overall survival for hepatocellular carcinoma.
Article in Journal of clinical laboratory analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Significant association between high neutrophil-lymphocyte ratio and poor prognosis in patients with hepatocellular carcinoma: a systematic review and meta-analysis.Frontiers in immunology · 2023Pooled it
- Prognostic role of indoleamine 2,3-dioxygenase 1 expression in solid tumors: A systematic review and meta-analysis.Frontiers in oncology · 2022Pooled it
- Evaluation of the effects of Theranekron and Sorafenib treatments on alpha-fetoprotein, heat shock protein 90 alpha and indoleamine 2,3 dioxygenase 1 enzyme levels in experimental hepatocellular carcinoma in rats.Molecular biology reports · 2025Article
- The relationship between tumor-infiltrating neutrophils and clinical outcomes in patients with resectable hepatocellular carcinoma.BMC cancer · 2024Article
- Neutrophils as potential therapeutic targets in hepatocellular carcinoma.Nature reviews. Gastroenterology & hepatology · 2022Review
- The effect of theJournal of gastrointestinal oncology · 2021Article
- The aryl hydrocarbon receptor in liver inflammation.Seminars in immunopathology · 2021Review
- Tumor-Associated Neutrophils in Hepatocellular Carcinoma Pathogenesis, Prognosis, and Therapy.Cancers · 2021Review
- Emerging Roles on Immunological Effect of Indoleamine 2,3-Dioxygenase in Liver Injuries.Frontiers in medicine · 2021Review
- A narrative review of the roles of indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in liver diseases.Annals of translational medicine · 2021Review
- Correlation Patterns Among B7 Family Ligands and Tryptophan Degrading Enzymes in Hepatocellular Carcinoma.Frontiers in oncology · 2020Article
- IDO and intra-tumoral neutrophils were independent prognostic factors for overall survival for hepatocellular carcinoma.Journal of clinical laboratory analysis · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundBoth Indole-amine-2,3-dioxygenase (IDO) and neutrophils were proved to have pro-tumor effect in some kinds of solid tumors by immune suppression. However, little is known about their effect on hepatocellular carcinoma (HCC) and the relationship between these two immune-suppressive factors. The aim of this study was to evaluate the prognostic significance of IDO and intra-tumoral neutrophils and their correlations in HCC.
methodsSpecimens' tissue microarray (TMA) for 153 HCC patients was used in this study. We examined intra-tumoral expression of IDO and CD66b in TMA. The Kaplan-Meier method and Cox regression models were used to evaluate the prognostic value of IDO expression and CD66b.
resultsMultivariate analysis showed both IDO expression and intra-tumoral neutrophils infiltration were independent prognostic factors for overall survival (OS). In high IDO expression group, the percentage of intra-tumoral neutrophils infiltration was higher than that in low IDO expression group.
conclusionBoth IDO and intra-tumoral neutrophils were independent prognostic factors for overall survival for HCC.
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