Evidence map›Paper›PMID 30843220›Full record

ArticleClinical cardiology2019

Electrocardiographic findings in peripartum cardiomyopathy.

Michael C Honigberg, Uri Elkayam, Navin Rajagopalan, Kalgi Modi, Joan E Briller, Mark H Drazner, Gretchen L Wells, Dennis M McNamara, Michael M Givertz, IPAC Investigators

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Clinical cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. The association of heart rate with adverse outcomes and recurrent heart failure hospitalization in peripartum cardiomyopathy.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Article
  4. Review
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  7. Review
  8. Article
  9. Article
  10. Peripartum Cardiomyopathy: Risks Diagnosis and Management.Journal of multidisciplinary healthcare · 2023
    Review
  11. Peripartum Cardiomyopathy.Journal of obstetrics and gynaecology of India · 2022
    Review
  12. Article
  13. Cardiomyopathies: An Overview.International journal of molecular sciences · 2021
    Review
  14. [Bradycardia in pregnancy : Case report and review of the literature].Herzschrittmachertherapie & Elektrophysiologie · 2021
    Review
  15. ECG and arrhythmias in peripartum cardiomyopathy.Herzschrittmachertherapie & Elektrophysiologie · 2021
    Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

Michael C HonigbergCardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Uri ElkayamDivision of Cardiovascular Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Navin RajagopalanHeart Failure and Transplant Cardiology, Newark Beth Israel Medical Center, Newark, New Jersey.
Kalgi ModiDivision of Cardiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
Joan E BrillerDivision of Cardiology, University of Illinois at Chicago, Chicago, Illinois.
Mark H DraznerDivision of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas.
Gretchen L WellsHeart Failure and Transplant Cardiology, Newark Beth Israel Medical Center, Newark, New Jersey.
Dennis M McNamaraHeart and Vascular Institute, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Michael M GivertzCardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID https://orcid.org/0000-0003-1012-7710
IPAC Investigators
Newark Beth Israel Medical Center · USBrigham and Women's Hospital · USHarvard University · USLouisiana State University Health Sciences Center Shreveport · USThe University of Texas Southwestern Medical Center · USUniversity of Illinois Chicago · USUniversity of Pittsburgh Medical Center · USUniversity of Southern California · US

Funding

Racial Genomic Differences and Heart Failure OutcomesK24HL069912 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCNAMARA, DENNIS M. · 2002 to 2013
$1.4M
Immune Activation and Myocardial Recovery in Peripartum CardiomyopathyRC1HL102429 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCNAMARA, DENNIS M. · 2009 to 2010
$1000k
NHLBI NIH HHS K24 HL069912NHLBI NIH HHS RC1 HL102429NIH HHS HL069912NIH HHS HL102429
6 · The paper itself

Abstract

backgroundThere is limited data on electrocardiographic (ECG) abnormalities and their prognostic significance in women with peripartum cardiomyopathy (PPCM). We sought to characterize ECG findings in PPCM and explore the association of ECG findings with myocardial recovery and clinical outcomes. HYPOTHESIS: We hypothesized that ECG indicators of myocardial remodeling would portend worse systolic function and outcomes.

methodsStandard 12-lead ECGs were obtained at enrollment in the Investigations of Pregnancy-Associated Cardiomyopathy study and analyzed for 88 women. Left ventricular ejection fraction (LVEF) was measured by echocardiography at baseline, 6 months, and 12 months. Women were followed for clinical events (death, mechanical circulatory support, and/or cardiac transplantation) until 1 year.

resultsHalf of women had an "abnormal" ECG, defined as atrial abnormality, ventricular hypertrophy, ST-segment deviation, and/or bundle branch block. Women with left atrial abnormality (LAA) had lower LVEF at 6 months (44% vs 52%, P = 0.02) and 12 months (46% vs 54%, P = 0.03). LAA also predicted decreased event-free survival at 1 year (76% vs 97%, P = 0.008). Neither left ventricular hypertrophy by ECG nor T-wave abnormalities predicted outcomes. A normal ECG was associated with recovery in LVEF to ≥50% (84% vs 49%, P = 0.001) and event-free survival at 1 year (100% vs 85%, P = 0.01).

conclusionsECG abnormalities are common in women with PPCM, but a normal ECG does not rule out the presence of PPCM. LAA predicted lower likelihood of myocardial recovery and event-free survival, and a normal ECG predicted favorable event-free survival.

Indexed as

Action PotentialsElectrocardiographyHeart RatePeripartum PeriodAdultCardiomyopathiesFemaleHumansNorth AmericaPredictive Value of TestsPregnancyProgression-Free SurvivalPuerperal DisordersRecovery of FunctionStroke VolumeTime Factorselectrocardiographymaternal-fetal healthoutcomesperipartum cardiomyopathy

Identifiers

PMID30843220
PMCPMC6522992
OpenAlexW2921652135

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.