ArticleThe Journal of physiology2019
Recruitment of non-perfused sublingual capillaries increases microcirculatory oxygen extraction capacity throughout ascent to 7126 m.
Article in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Change in pulmonary artery pressure upon acute exposure to high altitude: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Partial Pressure of Arterial Oxygen in Healthy Adults at High Altitudes: A Systematic Review and Meta-Analysis.JAMA network open · 2023Pooled it
- Right Ventricular Response to Acute Hypoxia Exposure: A Systematic Review.Frontiers in physiology · 2021Pooled it
- Mechanisms underlying end-organ injury in sleep apnoea.The European respiratory journal · 2026Review
- Improved Detection of Capillaries in High-Resolution Handheld Vital Microscopy by Use of the MicroTools Advanced Computer Vision Algorithm.Microcirculation (New York, N.Y. : 1994) · 2026Article
- Cardiovascular Effects of Long-Term Treatment with Enhanced External Counterpulsation in Patients with Ischemic Heart Failure: Randomized, Placebo-Controlled, Open-Label Clinical Trial.Journal of cardiovascular development and disease · 2025Article
- The effect of major abdominal surgery on the sublingual microcirculation: an observational study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025Observational
- Clinical value of sublingual microcirculatory dysfunction for screening for primary aldosteronism in hypertensive patients.Frontiers in endocrinology · 2025Article
- Nitroglycerin challenge identifies microcirculatory target for improved resuscitation in patients with circulatory shock.Intensive care medicine experimental · 2024Article
- The physiological basis for individualized oxygenation targets in critically ill patients with circulatory shock.Intensive care medicine experimental · 2024Review
- The microcirculation in the first days of ICU admission in critically ill COVID-19 patients is influenced by severity of disease.Scientific reports · 2024Article
- Sublingual microcirculatory alterations in Chagas disease: an observational study in an endemic rural population.Memorias do Instituto Oswaldo Cruz · 2024Observational
- Local carbachol application induces oral microvascular recruitment and improves gastric tissue oxygenation during hemorrhagic shock in dogs.Frontiers in immunology · 2024Article
- Novelties in the evaluation of microcirculation in septic shock.Journal of intensive medicine · 2023Review
- Microcirculatory and Rheological Adaptive Mechanisms at High Altitude in European Lowlander Hikers and Nepalese Highlanders.Journal of clinical medicine · 2023Article
- Microcirculatory alterations in critically ill COVID-19 patients analyzed using artificial intelligence.Critical care (London, England) · 2022Article
- Microcirculatory Alterations in Critically Ill Patients with COVID-19-Associated Acute Respiratory Distress Syndrome.Journal of clinical medicine · 2022Article
- Microcirculation alterations in severe COVID-19 pneumonia.Journal of critical care · 2021Observational
- Effects of Normoxia, Hyperoxia, and Mild Hypoxia on Macro-Hemodynamics and the Skeletal Muscle Microcirculation in Anesthetised Rats.Frontiers in medicine · 2021Article
- Veno-arterial thrombosis and microcirculation imaging in a patient with COVID-19.Respiratory medicine case reports · 2021Article
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key pointsA physiological response to increase microcirculatory oxygen extraction capacity at high altitude is to recruit capillaries. In the present study, we report that high altitude-induced sublingual capillary recruitment is an intrinsic mechanism of the sublingual microcirculation that is independent of changes in cardiac output, arterial blood pressure or systemic vascular hindrance. Using a topical nitroglycerin challenge to the sublingual microcirculation, we show that high altitude-related capillary recruitment is a functional response of the sublingual microcirculation as opposed to an anatomical response associated with angiogenesis. The concurrent presence of a low capillary density and high microvascular reactivity to topical nitroglycerin at sea level was found to be associated with a failure to reach the summit, whereas the presence of a high baseline capillary density with the ability to further increase maximum recruitable capillary density upon ascent to an extreme altitude was associated with summit success. ABSTRACT: A high altitude (HA) stay is associated with an increase in sublingual capillary total vessel density (TVD), suggesting microvascular recruitment. We hypothesized that microvascular recruitment occurs independent of cardiac output changes, that it relies on haemodynamic changes within the microcirculation as opposed to structural changes and that microcirculatory function is related to individual performance at HA. In 41 healthy subjects, sublingual handheld vital microscopy and echocardiography were performed at sea level (SL), as well as at 6022 m (C2) and 7042 m (C3), during ascent to 7126 m within 21 days. Sublingual topical nitroglycerin was applied to measure microvascular reactivity and maximum recruitable TVD (TVD
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.