ArticleClinical & experimental metastasis2019
Salvage treatment for recurrences after first resection of colorectal liver metastases: the impact of histopathological growth patterns.
Article in Clinical & experimental metastasis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Preoperative systemic chemotherapy alters the histopathological growth patterns of colorectal liver metastases.The journal of pathology. Clinical research · 2022Trial
- Resect first in resectable colorectal liver metastases: Recalibrating the default.Annals of hepato-biliary-pancreatic surgery · 2026Article
- Resection Margin Status, Recurrence Pattern, and Salvageability After Resection for Colorectal Liver Metastases.Annals of surgical oncology · 2026Article
- Prognostic value of desmoplastic growth patterns in resected hepatocellular carcinoma.Scientific reports · 2026Article
- New prognostic and predictive scoring systems for colorectal cancer liver metastases.ESMO open · 2026Review
- Encapsulated histopathological growth pattern of colorectal liver metastases predicts prolonged survival after repeat liver resection for recurrence.Clinical & experimental metastasis · 2026Article
- Classifying histopathological growth patterns for resected colorectal liver metastasis with a deep learning analysis.BJS open · 2024Article
- Histopathological Growth Patterns Determine the Outcomes of Colorectal Cancer Liver Metastasis Following Liver Resection.Cancers · 2024Article
- Histopathological growth patterns and tumor-infiltrating lymphocytes in breast cancer liver metastases.NPJ breast cancer · 2023Article
- The Effect of Histopathological Growth Patterns of Colorectal Liver Metastases on the Survival Benefit of Adjuvant Hepatic Arterial Infusion Pump Chemotherapy.Annals of surgical oncology · 2023Article
- Prognostic Significance of the Histopathological Growth Pattern and Tumor-Infiltrating Lymphocytes in Stratifying Survival After Hepatectomy for Colorectal Liver Metastases.Annals of surgical oncology · 2023Article
- The Histopathological Growth Pattern of Colorectal Liver Metastases Impacts Local Recurrence Risk and the Adequate Width of the Surgical Margin.Annals of surgical oncology · 2022Article
- Clinical implications and mechanism of histopathological growth pattern in colorectal cancer liver metastases.World journal of gastroenterology · 2022Review
- Predicting 10-year survival after resection of colorectal liver metastases; an international study including biomarkers and perioperative treatment.European journal of cancer (Oxford, England : 1990) · 2022Article
- A Comprehensive Prognostic Model for Colorectal Cancer Liver Metastasis Recurrence After Neoadjuvant Chemotherapy.Frontiers in oncology · 2022Article
- Contemporary evidence on colorectal liver metastases ablation: toward a paradigm shift in locoregional treatment.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2022Article
- Histopathological Growth Patterns and Survival After Resection of Colorectal Liver Metastasis: An External Validation Study.JNCI cancer spectrum · 2021Article
- Clinico-metabolic characterization improves the prognostic value of histological growth patterns in patients undergoing surgery for colorectal liver metastases.Journal of surgical oncology · 2021Article
- Different Forms of Tumor Vascularization and Their Clinical Implications Focusing on Vessel Co-option in Colorectal Cancer Liver Metastases.Frontiers in cell and developmental biology · 2021Review
- Histopathological growth patterns correlate with the immunoscore in colorectal cancer liver metastasis patients after hepatectomy.Cancer immunology, immunotherapy : CII · 2020Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The majority of patients recur after resection of colorectal liver metastases (CRLM). Patients with CRLM displaying a desmoplastic histopathological growth pattern (dHGP) have a better prognosis and lower probability of recurrence than patients with non-dHGP CRLM. The current study evaluates the impact of HGP type on the pattern and treatment of recurrences after first resection of CRLM. A retrospective cohort study was performed, including patients with known HGP type after complete resection of CRLM. All patients were treated between 2000 and 2015. The HGP was determined on the CRLM resected at first partial hepatectomy. The prognostic value of HGPs, in terms of survival outcome, in the current patient cohort were previously published. In total 690 patients were included, of which 492 (71%) developed recurrent disease. CRLM displaying dHGP were observed in 103 patients (21%). Amongst patients with dHGP CRLM diagnosed with recurrent disease, more liver-limited recurrences were seen (43% vs. 31%, p = 0.030), whereas patients with non-dHGP more often recurred at multiple locations (34% vs. 19%, p = 0.005). Patients with dHGP CRLM were more likely to undergo curatively intended local treatment for recurrent disease (adjusted odds ratio: 2.37; 95% confidence interval (CI) [1.46-3.84]; p < 0.001) compared to patients with non-dHGP. The present study demonstrates that liver-limited disease recurrence after complete resection of CRLM is more often seen in patients with dHGP, whereas patients with non-dHGP more frequently experience multi-organ recurrence. Recurrences in patients with dHGP at first CRLM resection are more likely to be salvageable by local treatment modalities, but no prognostic impact of HGPs after salvage therapy for recurrent disease was found.
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