ArticleEuropean journal of nutrition2020
Effectiveness of increased salt iodine concentration on iodine status: trend analysis of cross-sectional national studies in Switzerland.
Article in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02312466 (Swiss National Iodine Survey 2015; A Cross-sectional Study to Assess Iodine Status in School Children, Women of Reproductive Age and Pregnant Women), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Swiss National Iodine Survey 2015; A Cross-sectional Study to Assess Iodine Status in School Children, Women of Reproductive Age and Pregnant Women
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- A systematic review of iodine intake in children, adults, and pregnant women in Europe-comparison against dietary recommendations and evaluation of dietary iodine sources.Nutrition reviews · 2022Pooled it
- A randomized, double-blind study of iodine supplementation during pregnancy in Sweden: pilot evaluation of maternal iodine status and thyroid function.European journal of nutrition · 2021Trial
- Iron status in women of reproductive age in Switzerland: the role of inflammation and ferritin thresholds for the prevalence of iron deficiency-a cross-sectional study.European journal of clinical nutrition · 2026Article
- Cross sectional study on the prevalence and associated factors of iodine status in the population of Lausanne.Scientific reports · 2025Article
- Nutritional iodine intake in patients with anorexia nervosa.European thyroid journal · 2025Observational
- Iodine nutritional status in different trimesters of pregnancy and its association with dietary habits: a prospective observational study in Taiwan.BMC pregnancy and childbirth · 2025Observational
- Association between urinary heavy metal/trace element concentrations and kidney function: a prospective study.Clinical kidney journal · 2025Article
- Investigating thyroid function and iodine status in adolescents with and without paediatric major depressive disorder.The British journal of nutrition · 2024Article
- Adequate iodine nutrition and higher salt intake in Chinese adults aged 18-59 years recommended by international organizations.Scientific reports · 2024Article
- Iodine intake in the Swiss population 100 years after the introduction of iodised salt: a cross-sectional national study in children and pregnant women.European journal of nutrition · 2024Article
- Thyroid function and urinary concentrations of iodine, selenium, and arsenic in vegans, lacto-ovo vegetarians and pescatarians.European journal of nutrition · 2023Article
- Optimizing Growth: The Case for Iodine.Nutrients · 2023Review
- Iodine deficiency and real-life supplementation ineffectiveness in Polish pregnant women and its impact on thyroid metabolism.Frontiers in endocrinology · 2023Article
- The Role of Iodine for Thyroid Function in Lactating Women and Infants.Endocrine reviews · 2022Review
- Salt reduction and iodine intake in Italy.Journal of endocrinological investigation · 2022Article
- The Role of Multiply-Fortified Table Salt and Bouillon in Food Systems Transformation.Nutrients · 2022Article
- Iodine content of frequently used prenatal and adult multivitamins in Switzerland.Frontiers in endocrinology · 2022Article
- Swiss Cohort & Biobank - The White Paper.Public health reviews · 2022Article
- A Household-Based Survey of Iodine Nutrition in Moroccan Children Shows Iodine Sufficiency at the National Level But Risk of Deficient Intakes in Mountainous Areas.Children (Basel, Switzerland) · 2021Article
- Inadequate Status and Low Awareness of Folate in Switzerland-A Call to Strengthen Public Health Measures to Ensure Sufficient Intakes.Nutrients · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeDespite longstanding voluntary salt iodisation in Switzerland, data suggest inadequate iodine intake in vulnerable population groups. In response, the salt iodine concentration was increased from 20 to 25 mg/kg and we assessed the impact on iodine status.
methodsWe conducted a cross-sectional national study in school-age children (n = 731), women of reproductive age (n = 353) and pregnant women (n = 363). We measured urinary iodine concentration (UIC) and urinary sodium concentration (UNaC) in spot urine samples. The current median UIC was compared with national data from 1999, 2004 and 2009. We measured TSH, total T4 and thyroglobulin (Tg) on dried blood spot samples collected in women.
resultsThe median UIC (bootstrapped 95% CI) was 137 µg/L (131, 143 µg/L) in school children, 88 µg/L (72, 103 µg/L) in women of reproductive age and 140 µg/L (124, 159 µg/L) in pregnant women. Compared to 2009, the median UIC increased modestly in school children (P < 0.001), but did not significantly change in pregnant women (P = 0.417). Estimated sodium intake exceeded the recommendations in all population groups. The prevalence of thyroid disorders in women was low, but Tg was elevated in 13% of the pregnant women.
conclusionIodine intake is overall adequate in Swiss school-age children, but only borderline sufficient in pregnant and non-pregnant women, despite high salt intakes and satisfactory household coverage with iodized salt. Our findings suggest increasing the concentration of iodine in salt may not improve iodine intakes in women if iodised salt is not widely used in processed foods. REGISTRATION: This trial was registered at clinicaltrials.gov as NCT02312466.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.