Evidence map›Paper›PMID 30843095›Full record

ArticleNeuroradiology2019

Altered coupling of spontaneous brain activities and brain temperature in patients with adolescent-onset, first-episode, drug-naïve schizophrenia.

Zhiyong Zhao, Guojun Xu, Bin Sun, Xuzhou Li, Zhe Shen, Shangda Li, Yi Xu, Manli Huang, Dongrong Xu

Abstract read
PubMed Publisher
In one paragraph

Article in Neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Zhiyong ZhaoShanghai Key Laboratory of Magnetic Resonance, Key Laboratory of Brain Functional Genomics (MOE & STCSM), Institute of Cognitive Neuroscience, East China Normal University, Shanghai, 200062, China.
Guojun XuShanghai Key Laboratory of Magnetic Resonance, Key Laboratory of Brain Functional Genomics (MOE & STCSM), Institute of Cognitive Neuroscience, East China Normal University, Shanghai, 200062, China.
Bin SunCollege of Medicine, Zhejiang University, No. 268, Kaixuan Road, Hangzhou, 310000, China.
Xuzhou LiDepartment of Psychiatry & New York State Psychiatric Institute, Columbia University, 1051 Riverside Drive, New York, NY, 10032, USA.
Zhe ShenCollege of Medicine, Zhejiang University, No. 268, Kaixuan Road, Hangzhou, 310000, China.
Shangda LiCollege of Medicine, Zhejiang University, No. 268, Kaixuan Road, Hangzhou, 310000, China.
Yi XuDepartment of Psychiatry, The First Affiliated Hospital, The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Manli HuangDepartment of Psychiatry, The First Affiliated Hospital, The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Dongrong XuDepartment of Psychiatry & New York State Psychiatric Institute, Columbia University, 1051 Riverside Drive, New York, NY, 10032, USA. xu.dongrong@columbia.edu.ORCID http://orcid.org/0000-0003-4682-1587
Zhejiang University · CNNew York Psychoanalytic Society and Institute · US

Funding

Basic Public Welfare Research Projects in Zhejiang Province LGF18H090003China National Key R&D Program 2016YFC1307005China National Key R&D Program 2017YFC1308500China National Key R&D Program 2017YFC1308502China National Science Foundation 81471734Major Subject of Zhejiang Province 2015C03054
6 · The paper itself

Abstract

purposeA recent study has reported that schizophrenia patients show an uncoupled association between intraventricular brain temperature (BT) and cerebral blood flow (CBF). CBF has been found to be closely coupled with spontaneous brain activities (SBAs) derived from resting-state BOLD fMRI metrics. Yet, it is unclear so far whether the relationship between the intraventricular BT and the SBAs may change in patients with adolescent-onset schizophrenia (AOS) compared with that in healthy controls (HCs).

methodsThe present study recruited 28 first-episode, drug-naïve AOS patients and 22 matched HCs. We measured the temperature of the lateral ventricles (LV) using diffusion-weighted imaging thermometry and measured SBAs using both regional homogeneity and amplitude of low-frequency fluctuation methods. A nonparametric Wilcoxon rank sum test was used to detect the difference in intraventricular BT between AOS patients and HCs with LV volume, age, and sex as covariates. We also evaluated the relationship between the intraventricular BT and the SBAs using partial correlation analysis controlling for LV volume, age, and sex.

resultsWe found that HCs showed a significant negative correlation between the intraventricular BT and the local SBAs in the bilateral putamina and left superior temporal gyrus, while such a correlation was absent in AOS patients. Additionally, no significant difference between the two groups was found in the intraventricular BT.

conclusionThese findings suggest that AOS patients may experience an uncoupling between intraventricular BT and SBAs in several schizophrenia-related brain areas, which may be associated with the altered relationships among intraventricular BT, CBF, and metabolism.

Indexed as

AdolescentAge of OnsetBody TemperatureBrainCase-Control StudiesCerebrovascular CirculationDiffusion Magnetic Resonance ImagingFemaleHumansImage Interpretation, Computer-AssistedMaleSchizophreniaThermometryAdolescent-onset schizophreniaDiffusion-weighted imaging thermometryIntraventricular brain temperatureResting-state fMRISpontaneous brain activities

Identifiers

PMID30843095
OpenAlexW2922116229

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.