Evidence map›Paper›PMID 30843051›Full record

ArticleEuropean heart journal. Quality of care & clinical outcomes2019

Risk factors for 'microsize' vs. usual myocardial infarctions in the REasons for Geographic and Racial Differences in Stroke (REGARDS) study.

Zaid I Almarzooq, Lisandro D Colantonio, Peter M Okin, Joshua S Richman, Todd M Brown, Emily B Levitan, Joanna Bryan, Monika M Safford

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal. Quality of care & clinical outcomes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Zaid I AlmarzooqDivision of Cardiovascular Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, USA.
Lisandro D ColantonioDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Peter M OkinDivision of Cardiology, 525 East 68th Street, F-2006, New York, NY, USA.
Joshua S RichmanDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Todd M BrownDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
Emily B LevitanDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Joanna BryanDivision of General Internal Medicine, Weill Cornell Medicine, 525 East 68th Street, F-2006, New York, NY, USA.
Monika M SaffordDivision of General Internal Medicine, Weill Cornell Medicine, 525 East 68th Street, F-2006, New York, NY, USA.
University of Alabama at Birmingham · USWeill Cornell Medicine · USBrigham and Women's Hospital · US

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

aimsA recently described phenomenon is that of myocardial infarction (MI) events that meet criteria for MI, but that have very low peak troponin elevations, so-called 'microsize MI'. These events are very common and associated with increased risk of all-cause mortality. Our aim is to compare risk factors for microsize MI vs. usual MI events. METHODS AND

resultsAmong 24 470 participants of the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort free of coronary heart disease at baseline, heart-related hospitalizations were expert adjudicated for MI using published guidelines. Myocardial infarctions were classified as microsize MI (peak troponin <0.5 ng/mL) or usual MI (peak troponin ≥0.5 ng/mL). Competing risk analyses assessed associations between baseline risk factors and incident microsize vs. usual MI. Between 2003 and 2013 there were 891 MIs; 279 were microsize MI and 612 were usual MI. Risk factors for both usual MI and microsize MI include age, gender, diabetes, and urinary albumin to creatinine ratio. Risk factors for only usual MI include Residence in the Stroke Belt and Buckle regions and current smoking. Black race was associated with a uniquely lower risk of usual MI.

conclusionThe similarities in risk profiles suggest a possible common aetiology and should encourage clinicians to both treat reversible risk factors for microsize MI and to initiate secondary prevention strategies following these events until this emerging clinical entity is better understood. Future studies should further assess the clinical outcomes of these two entities and their effect on future management.

Indexed as

Black or African AmericanWhite PeopleAgedFemaleHumansMaleMiddle AgedMyocardial InfarctionProspective StudiesRisk FactorsStrokeTroponinUnited StatesTroponinAcute coronary syndromeMicrosize MIMortalityRisk factorsTroponin

Identifiers

PMID30843051
PMCPMC7967788
OpenAlexW2921734891

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.