Evidence map›Paper›PMID 30842984›Full record

ArticleACS omega2019

Novel 2-(5-Imino-5

Alissar Monzer, Nayri Jabotian, Farah Ballout, Jie S Zhu, Mark J Kurth, Makhluf J Haddadin, Hala Gali-Muhtasib

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Alissar MonzerDepartment of Biology, and Center for Drug Discovery, and Department of Chemistry, American University of Beirut, Riad El Solh, 1107 2020 Beirut, Lebanon.
Nayri JabotianDepartment of Biology, and Center for Drug Discovery, and Department of Chemistry, American University of Beirut, Riad El Solh, 1107 2020 Beirut, Lebanon.
Farah BalloutDepartment of Biology, and Center for Drug Discovery, and Department of Chemistry, American University of Beirut, Riad El Solh, 1107 2020 Beirut, Lebanon.
Jie S ZhuDepartment of Chemistry, University of California at Davis, One Shields Avenue, Davis, California 95616-5295, United States.
Mark J KurthDepartment of Chemistry, University of California at Davis, One Shields Avenue, Davis, California 95616-5295, United States.
Makhluf J HaddadinDepartment of Biology, and Center for Drug Discovery, and Department of Chemistry, American University of Beirut, Riad El Solh, 1107 2020 Beirut, Lebanon.
Hala Gali-MuhtasibDepartment of Biology, and Center for Drug Discovery, and Department of Chemistry, American University of Beirut, Riad El Solh, 1107 2020 Beirut, Lebanon.
American University of Beirut · LBUniversity of California, Davis · US

Funding

SynthesisP30DK072517 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VERKMAN, ALAN S · 2005 to 2022
$18.1M
XENOBIOTICS AND PRIMARY BILIARY CIRRHOSISR01DK067003 · NIDDK · UNIVERSITY OF CALIFORNIA DAVIS · PI GERSHWIN, MERRILL E · 2003 to 2017
$4.4M
NIDDK NIH HHS P30 DK072517NIDDK NIH HHS R01 DK067003
6 · The paper itself

Abstract

Chemotherapy has been shown to be effective in reducing the progression and development of cancer in metastatic patients. However, drug selectivity is still a major issue for most chemotherapeutics. In this study, we synthesized four novel heterocyclic compounds having similarity in structure with quinone systems whereby nitrogen atoms replace the oxygen atoms. The anticancer activity of these compounds (

Identifiers

PMID30842984
PMCPMC6396124
OpenAlexW2914257392

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.