ArticleWorld journal of clinical cases2019
Primary leiomyosarcoma of the thyroid gland with prior malignancy and radiotherapy: A case report and review of literature.
Article in World journal of clinical cases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Integrative diagnostic approach in a rare case of primary thyroid leiomyosarcoma with distant metastasis: a case report and literature review.Gland surgery · 2025Article
- Primary leiomyosarcoma of the thyroid with concurrent papillary thyroid cancer: a rare case report and a review of literature.Thyroid research · 2023Article
- Primary thyroid leiomyosarcoma with transvenous extension to the right atrium: a case report.European heart journal. Case reports · 2022Article
- Primary thyroid leiomyosarcoma: a diagnostic and therapeutic challenge.BMJ case reports · 2021Review
- Diagnostic Value of Preoperative CA125, LDH and HE4 for Leiomyosarcoma of the Female Reproductive System.Cancer management and research · 2021Article
- Comprehensive guidance on the diagnosis and management of primary mesenchymal tumours of the thyroid gland.The Lancet. Oncology · 2020Review
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
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Abstract
backgroundLeiomyosarcoma (LMS) of the thyroid gland is a rarely presented tumor that offers poor prognosis. To the best of the authors' knowledge, there currently exist only 28 known cases described in the literature (limited to English). CASE SUMMARY: Herein a case is reported of a 60-year-old female patient who had an LMS of the thyroid, which was accompanied by periodic dysphonia and breathing disorder as well as the feeling of pressure in the chest and neck. At the time the disease was diagnosed, no metastases were detected. Prior to the diagnosis, the patient experienced a uterine adenocarcinoma that had been treated by surgical procedure and radiotherapy. For the LMS, a total thyroidectomy was performed, followed by radiotherapy. Since metastases were also discovered in the lungs, sternum, and femur, chemotherapy was administered as well. Immunohistochemically, the tumor cells in the thyroid indicated positively for alpha smooth muscle actin, calponin, and H-caldesmon, but were negative for CD34, p63, estrogen receptor, progesterone receptor, and Epstein-Barr virus.
conclusionAlthough the etiology of the LMS is as of yet unknown, prior malignancy and radiation should be considered as risk factors.
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