Evidence map›Paper›PMID 30842835›Full record

ArticleChemical science2019

Sensitively distinguishing intracellular precursor and mature microRNA abundance.

Fan Yang, Yaru Cheng, Yu Cao, Haifeng Dong, Huiting Lu, Kai Zhang, Xiangdan Meng, Conghui Liu, Xueji Zhang

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
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  3. An overview of biochemical technologies for the cancer biomarker miR-21 detection.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Fan YangBeijing Advanced Innovation Center for Materials Genome Engineering , University of Science and Technology Beijing , 30 Xueyuan Road , Beijing 100083 , P. R. China . Email: hfdong@ustb.edu.cn ; Email: zhangxueji@ustb.edu.cn.
Yaru ChengBeijing Advanced Innovation Center for Materials Genome Engineering , University of Science and Technology Beijing , 30 Xueyuan Road , Beijing 100083 , P. R. China . Email: hfdong@ustb.edu.cn ; Email: zhangxueji@ustb.edu.cn.
Yu CaoBeijing Advanced Innovation Center for Materials Genome Engineering , University of Science and Technology Beijing , 30 Xueyuan Road , Beijing 100083 , P. R. China . Email: hfdong@ustb.edu.cn ; Email: zhangxueji@ustb.edu.cn.
Haifeng DongBeijing Advanced Innovation Center for Materials Genome Engineering , University of Science and Technology Beijing , 30 Xueyuan Road , Beijing 100083 , P. R. China . Email: hfdong@ustb.edu.cn ; Email: zhangxueji@ustb.edu.cn.ORCID 0000-0002-6907-6578
Huiting LuBeijing Advanced Innovation Center for Materials Genome Engineering , University of Science and Technology Beijing , 30 Xueyuan Road , Beijing 100083 , P. R. China . Email: hfdong@ustb.edu.cn ; Email: zhangxueji@ustb.edu.cn.ORCID 0000-0001-6629-3633
Kai ZhangBeijing Advanced Innovation Center for Materials Genome Engineering , University of Science and Technology Beijing , 30 Xueyuan Road , Beijing 100083 , P. R. China . Email: hfdong@ustb.edu.cn ; Email: zhangxueji@ustb.edu.cn.
Xiangdan MengBeijing Advanced Innovation Center for Materials Genome Engineering , University of Science and Technology Beijing , 30 Xueyuan Road , Beijing 100083 , P. R. China . Email: hfdong@ustb.edu.cn ; Email: zhangxueji@ustb.edu.cn.
Conghui LiuBeijing Advanced Innovation Center for Materials Genome Engineering , University of Science and Technology Beijing , 30 Xueyuan Road , Beijing 100083 , P. R. China . Email: hfdong@ustb.edu.cn ; Email: zhangxueji@ustb.edu.cn.
Xueji ZhangBeijing Advanced Innovation Center for Materials Genome Engineering , University of Science and Technology Beijing , 30 Xueyuan Road , Beijing 100083 , P. R. China . Email: hfdong@ustb.edu.cn ; Email: zhangxueji@ustb.edu.cn.
Beijing Advanced Sciences and Innovation Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mature microRNAs (miRNAs) produced from precursor microRNAs (pre-miRNAs) by the RNase Dicer have showed significant potential for cancer diagnosis and prognosis due to their key regulatory roles in various pathological processes. However, discriminatory detection of low-abundance miRNAs and pre-miRNAs remains a key challenge since the mature sequence is also present in the pre-miRNA forms. Herein, we report a novel cascade reaction to sensitively distinguish miRNAs

Identifiers

PMID30842835
PMCPMC6368210
OpenAlexW2902431728

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.