Evidence map›Paper›PMID 30842820›Full record

ArticleChemical science2019

A novel strategy for facile serum exosome isolation based on specific interactions between phospholipid bilayers and TiO

Fangyuan Gao, Fenglong Jiao, Chaoshuang Xia, Yang Zhao, Wantao Ying, Yuping Xie, Xiaoya Guan, Ming Tao, Yangjun Zhang, Weijie Qin and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it, 202 citations in OpenAlex.

  1. Diagnostic value of exosomes in patients with liver cancer: a systematic review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Pooled it
  2. Extracellular Vesicles and Their Role in Osteogenesis.Bioengineering (Basel, Switzerland) · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. TiOBioprocess and biosystems engineering · 2026
    Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Exosome enrichment from human serum using polyethylene glycol precipitation.Journal of analytical science and technology · 2025
    Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Fangyuan GaoState Key Laboratory of Proteomics , National Center for Protein Sciences (Beijing) , Beijing Institute of Lifeomics , Beijing Proteome Research Center , China . Email: qianxh1@163.com ; Email: 13683167093@163.com ; Email: aunp_dna@126.com.
Fenglong JiaoState Key Laboratory of Proteomics , National Center for Protein Sciences (Beijing) , Beijing Institute of Lifeomics , Beijing Proteome Research Center , China . Email: qianxh1@163.com ; Email: 13683167093@163.com ; Email: aunp_dna@126.com.ORCID 0000-0001-9980-3206
Chaoshuang XiaState Key Laboratory of Proteomics , National Center for Protein Sciences (Beijing) , Beijing Institute of Lifeomics , Beijing Proteome Research Center , China . Email: qianxh1@163.com ; Email: 13683167093@163.com ; Email: aunp_dna@126.com.
Yang ZhaoState Key Laboratory of Proteomics , National Center for Protein Sciences (Beijing) , Beijing Institute of Lifeomics , Beijing Proteome Research Center , China . Email: qianxh1@163.com ; Email: 13683167093@163.com ; Email: aunp_dna@126.com.
Wantao YingState Key Laboratory of Proteomics , National Center for Protein Sciences (Beijing) , Beijing Institute of Lifeomics , Beijing Proteome Research Center , China . Email: qianxh1@163.com ; Email: 13683167093@163.com ; Email: aunp_dna@126.com.
Yuping XieState Key Laboratory of Proteomics , National Center for Protein Sciences (Beijing) , Beijing Institute of Lifeomics , Beijing Proteome Research Center , China . Email: qianxh1@163.com ; Email: 13683167093@163.com ; Email: aunp_dna@126.com.
Xiaoya GuanPeking University Cancer Hospital , China.
Ming TaoPeking University Third Hospital , China.
Yangjun ZhangState Key Laboratory of Proteomics , National Center for Protein Sciences (Beijing) , Beijing Institute of Lifeomics , Beijing Proteome Research Center , China . Email: qianxh1@163.com ; Email: 13683167093@163.com ; Email: aunp_dna@126.com.
Weijie QinState Key Laboratory of Proteomics , National Center for Protein Sciences (Beijing) , Beijing Institute of Lifeomics , Beijing Proteome Research Center , China . Email: qianxh1@163.com ; Email: 13683167093@163.com ; Email: aunp_dna@126.com.
Xiaohong QianState Key Laboratory of Proteomics , National Center for Protein Sciences (Beijing) , Beijing Institute of Lifeomics , Beijing Proteome Research Center , China . Email: qianxh1@163.com ; Email: 13683167093@163.com ; Email: aunp_dna@126.com.
Beijing Proteome Research Center · CNPeking University · CNBeijing Institute of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are cell-derived, phospholipid bilayer-enclosed vesicles that play important roles in intercellular interactions and regulate many biological processes. Accumulating evidence suggests that serum exosomes are potential biomarkers for the early diagnosis of cancer. To aid the downstream molecular analyses of tumour-secreted exosomes, purified exosomes are highly desirable. However, current techniques for exosome isolation are time-consuming and highly instrument-dependent, with limited specificity and recovery. Thus, rapid and efficient methods are strongly needed for both basic research and clinical applications. Here, we present a novel strategy for facile exosome isolation from human serum by taking advantage of the specific interaction of TiO

Identifiers

PMID30842820
PMCPMC6369439
OpenAlexW2903530962

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.