Evidence map›Paper›PMID 30842791›Full record

ArticleFrontiers in genetics2019

Age Dependent Dysfunction of Mitochondrial and ROS Metabolism Induced by Mitonuclear Mismatch.

Nicolas Pichaud, Roxanne Bérubé, Geneviève Côté, Claude Belzile, France Dufresne, Geneviève Morrow, Robert M Tanguay, David M Rand, Pierre U Blier

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Nicolas PichaudLaboratory of Comparative Biochemistry and Physiology, Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada.
Roxanne BérubéLaboratoire de Physiologie Animale Intégrative, Département de Biologie, Université du Québec à Rimouski, Rimouski, QC, Canada.
Geneviève CôtéLaboratoire de Physiologie Animale Intégrative, Département de Biologie, Université du Québec à Rimouski, Rimouski, QC, Canada.
Claude BelzileInstitut des Sciences de la mer de Rimouski, Université du Québec à Rimouski, Rimouski, QC, Canada.
France DufresneLaboratoire d'Écologie Moléculaire, Département de Biologie, Université du Québec à Rimouski, Rimouski, QC, Canada.
Geneviève MorrowLaboratoire de Génétique Cellulaire et Développementale, Département de Biologie Moléculaire, Biochimie Médicale et Pathologie, Université Laval, Quebec City, QC, Canada.
Robert M TanguayLaboratoire de Génétique Cellulaire et Développementale, Département de Biologie Moléculaire, Biochimie Médicale et Pathologie, Université Laval, Quebec City, QC, Canada.
David M RandDepartment of Ecology and Evolutionary Biology, Brown University, Providence, RI, United States.
Pierre U BlierLaboratoire de Physiologie Animale Intégrative, Département de Biologie, Université du Québec à Rimouski, Rimouski, QC, Canada.
Université du Québec à Rimouski · CAUniversité Laval · CABrown University · USUniversité de Moncton · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial and nuclear genomes have to coevolve to ensure the proper functioning of the different mitochondrial complexes that are assembled from peptides encoded by both genomes. Mismatch between these genomes is believed to be strongly selected against due to the consequent impairments of mitochondrial functions and induction of oxidative stress. Here, we used a

Indexed as

agingDrosophilamitochondrial respirationmitonuclear incompatibilityreactive oxygen speciesreplicationtRNA

Identifiers

PMID30842791
PMCPMC6391849
OpenAlexW2914774683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.