ReviewInternational journal of health sciences
Effect of chlorhexidine cord application on prevention of neonatal sepsis in developing countries: Systematic review and meta-analysis.
Review in International journal of health sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Mapping infant streptococcal mortality burden in low- and middle-income countries: temporal trends, geospatial patterns, and socioeconomic determinants.European journal of pediatrics · 2026Article
- Benchmarking newborn care quality in Ghana: Evidence from structured observations of clinical practice against WHO quality standards.PloS one · 2026Observational
- Incidence and Associated Factors of Cord Infection Among Neonates at Fort Portal and Hoima Regional Referral Hospitals.Infection and drug resistance · 2026Article
- Assessing the Knowledge, Practices and the Associated Factors Among Postpartum Mothers Concerning Neonatal Umbilical Cord Care in Pakistan: A Cross-Sectional Study.Maternal and child health journal · 2025Article
- Breast Milk Application as a Natural Method for Umbilical Cord Care: A Community-Label 3-Arm Pilot Clinical Trial.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2024Article
- Knowledge and use of chorhexidine gel in umbilical cord care among postpartum women at Poly General Hospital, Enugu, Southeast Nigeria: a cross-sectional study.International health · 2024Article
- Chlorhexidine cord care after a national scale-up as a newborn survival strategy: A survey in four regions of Ethiopia.PloS one · 2022Article
- Multilevel analysis of individual and community level factors associated with the application of cow dung and oil on the umbilical cord stump in Ethiopia.Frontiers in pediatrics · 2022Article
- Cause and predictors of neonatal mortality among neonates admitted to neonatal intensive care units of public hospitals in eastern Ethiopia: a facility-based prospective follow-up study.BMC pediatrics · 2020Article
- Neonatal Sepsis in Low-Resource Emergency Settings: Evidence-Based Strategies for Early Recognition and Management.Sage open pediatricsReview
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this review was to identify the pooled effect of chlorhexidine cord application on prevention of neonatal sepsis in developing countries.
methodsWe have conducted systemic review and meta-analysis. Articles were searched from electronic databases such as PubMed, EMBASE, CINHAL, Cochrane central register of controlled trials (CENTRAL), and other sources such as direct Google search, Google Scholar, and POPline. Only randomized controlled trial studies were considered for this review. The effect of chlorhexidine cord application on prevention of neonatal sepsis and mortality was assessed as compared to dry cord care.
resultsFive studies from developing countries were included in the review with a total of 129,293 participants. Pooled result of meta-analysis showed that chlorhexidine cord application reduces neonatal sepsis by 32% as compared to dry cord care (relative risk [RR] 0.68, 95% confidence interval [CI] 0.57-0.81, random effect model, I
conclusionsChlorhexidine cord application significantly reduces neonatal sepsis and mortality in developing countries. Therefore, we stress the importance of including chlorhexidine cord application into the essential newborn care in the setting with high burden of neonatal mortality. The review protocol was registered at PROSPERO with registration number CRD 42018089204.
Indexed as
Identifiers
30842717PMC6392487What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.