ArticleScientific reports2019
Ischaemic stroke in mice induces lung inflammation but not acute lung injury.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Immunomodulation for stroke-associated pneumonia: a systematic review of mechanistic insight and emerging therapeutic strategies in animal models.Frontiers in immunology · 2026Pooled it
- Advances in stroke-associated pneumonia in the era of revascularization therapy.Chinese medical journal · 2026Review
- Nogo-A is secreted in extracellular vesicles, occurs in blood and can influence vascular permeability.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Pulmonary consequences of experimentally induced stroke: differences between global and focal cerebral ischemia.Frontiers in physiology · 2024Article
- Expression of NGF, proNGF, p75Clinics (Sao Paulo, Brazil) · 2024Article
- Analysis of risk factors for pulmonary infection in acute ischemic stroke patients following intravenous thrombolysis with alteplase.American journal of translational research · 2024Article
- Targeted Nanocarriers Co-Opting Pulmonary Intravascular Leukocytes for Drug Delivery to the Injured Brain.ACS nano · 2023Article
- Systemic innate myeloid responses to acute ischaemic and haemorrhagic stroke.Seminars in immunopathology · 2023Review
- Mild Traumatic Brain Injury and Subsequent Acute Pulmonary Inflammatory Response.Journal of Korean Neurosurgical Society · 2022Article
- Inflammatory Responses After Ischemic Stroke.Seminars in immunopathology · 2022Review
- Evaluation and Characterization of Post-Stroke Lung Damage in a Murine Model of Cerebral Ischemia.International journal of molecular sciences · 2022Article
- NLRP3 Knockout Protects against Lung Injury Induced by Cerebral Ischemia-Reperfusion.Oxidative medicine and cellular longevity · 2022Article
- Brain to periphery in acute ischemic stroke: Mechanisms and clinical significance.Frontiers in neuroendocrinology · 2021Review
- Stroke-induced immunosuppression: implications for the prevention and prediction of post-stroke infections.Journal of neuroinflammation · 2021Review
- Stroke increases the expression of ACE2, the SARS-CoV-2 binding receptor, in murine lungs.Brain, behavior, and immunity · 2021Article
- Asthma and stroke: a narrative review.Asthma research and practice · 2021Review
- Short Chain Fatty Acids Taken at Time of Thrombectomy in Acute Ischemic Stroke Patients Are Independent of Stroke Severity But Associated With Inflammatory Markers and Worse Symptoms at Discharge.Frontiers in immunology · 2021Article
- Ischaemic stroke-induced distal organ damage: pathophysiology and new therapeutic strategies.Intensive care medicine experimental · 2020Review
- Lung SOD3 limits neurovascular reperfusion injury and systemic immune activation following transient global cerebral ischemia.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2020Article
- Mechanical ventilation in patients with acute ischemic stroke: from pathophysiology to clinical practice.Critical care (London, England) · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke is a major cause of death worldwide and ischemic stroke is the most common subtype accounting for approximately 80% of all cases. Pulmonary complications occur in the first few days to weeks following ischemic stroke and are a major contributor to morbidity and mortality. Acute lung injury (ALI) occurs in up to 30% of patients with subarachnoid haemorrhage but the incidence of ALI after ischemic stroke is unclear. As ischemic stroke is the most common subtype of stroke, it is important to understand the development of ALI following the initial ischemic injury to the brain. Therefore, this study investigated whether focal ischemic stroke causes lung inflammation and ALI in mice. Ischemic stroke caused a significant increase in bronchoalveolar lavage fluid (BALF) macrophages and neutrophils and whole lung tissue proinflammatory IL-1β mRNA expression but this did not translate into histologically evident ALI. Thus, it appears that lung inflammation, but not ALI, occurs after experimental ischemic stroke in mice. This has significant implications for organ donors as the lungs from patient's dying of ischemic stroke are not severely damaged and could thus be used for transplantation in people awaiting this life-saving therapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.