ArticleCellular & molecular immunology2020
The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection.
Open access · bronzeAbstract read
In one paragraph
Article in Cellular & molecular immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Application of Extracellular Vesicles in Allergic Rhinitis: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Oncolytic virotherapy mobilizes tumor-resident, granzyme B-producing bystander CD4Molecular therapy. Oncology · 2026Article
- Enhancer zeste homolog 2 (EZH2) targeting by small interfering RNA (siRNA); recent advances and prospect.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- KMT2D coordinates antiviral CD4Cell reports · 2025Article
- Predictive value of circulating PD-1Frontiers in medicine · 2025Article
- Themis differentially regulates T follicular helper cell differentiation during early and late stages of chronic viral infection.Frontiers in immunology · 2025Article
- Intracellular checkpoints for NK cell cancer immunotherapy.Frontiers of medicine · 2024Review
- An oncolytic virus delivering tumor-irrelevant bystander T cell epitopes induces anti-tumor immunity and potentiates cancer immunotherapy.Nature cancer · 2024Article
- Activation of mucosal insulin receptor exacerbates intestinal inflammation by promoting tissue resident memory T cells differentiation through EZH2.Journal of translational medicine · 2024Article
- The multifaceted roles of TCF1 in innate and adaptive lymphocytes.Advances in immunology · 2024Review
- Analysis on EZH2: mechanism identification of related CeRNA and its immunoassay in hepatocellular carcinoma.BMC medical genomics · 2023Article
- Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4Nature communications · 2023Article
- The Chromatin Regulator Mll1 Supports T Follicular Helper Cell Differentiation by Controlling Expression of Bcl6, LEF-1, and TCF-1.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Transcriptional and Epigenetic Regulation of Context-Dependent Plasticity in T-Helper Lineages.Immune network · 2023Review
- The Transcription Factor YY-1 Is an Essential Regulator of T Follicular Helper Cell Differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- TCF1 in T cell immunity: a broadened frontier.Nature reviews. Immunology · 2022Review
- EZH2: Its regulation and roles in immune disturbance of SLE.Frontiers in pharmacology · 2022Review
- EZH2 Promotes T Follicular Helper Cell Differentiation Through Enhancing STAT3 Phosphorylation in Patients With Primary Sjögren's Syndrome.Frontiers in immunology · 2022Article
- The Differentiation and Maintenance of SARS-CoV-2-Specific Follicular Helper T Cells.Frontiers in cellular and infection microbiology · 2022Review
- EZH2 restrictsFrontiers in immunology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 3 institutions in 2 countries.
Xiangyu Chen *Institute of Immunology, PLA, Third Military Medical University, 400038, Chongqing, China.
Guoshuai Cao *Institute for Molecular Engineering, University of Chicago, Chicago, IL, 60637, USA.
Jialin Wu *Institute of Immunology, PLA, Third Military Medical University, 400038, Chongqing, China.
Xinxin Wang *Institute of Cancer, Xinqiao Hospital, Third Military Medical University, 400038, Chongqing, China.
Zhiwei PanInstitute of Immunology, PLA, Third Military Medical University, 400038, Chongqing, China.
Jianbao GaoInstitute of Cancer, Xinqiao Hospital, Third Military Medical University, 400038, Chongqing, China.
Qin TianInstitute of Immunology, PLA, Third Military Medical University, 400038, Chongqing, China.
Lifan XuInstitute of Immunology, PLA, Third Military Medical University, 400038, Chongqing, China.
Zhirong LiInstitute of Immunology, PLA, Third Military Medical University, 400038, Chongqing, China.
Yaxing HaoInstitute of Immunology, PLA, Third Military Medical University, 400038, Chongqing, China.
Qizhao HuangCancer Center, The General Hospital of Western Theater Command, Chengdu, China.
Pengcheng WangInstitute of Immunology, PLA, Third Military Medical University, 400038, Chongqing, China.
Minglu XiaoInstitute of Immunology, PLA, Third Military Medical University, 400038, Chongqing, China.
Luoyingzi XieInstitute of Immunology, PLA, Third Military Medical University, 400038, Chongqing, China.
Shupei TangInstitute of Immunology, PLA, Third Military Medical University, 400038, Chongqing, China.
Zhenyu LiuInstitute of Immunology, PLA, Third Military Medical University, 400038, Chongqing, China.
Li HuInstitute of Immunology, PLA, Third Military Medical University, 400038, Chongqing, China.
Jianfang TangInstitute of Immunology, PLA, Third Military Medical University, 400038, Chongqing, China.
Ran HeInstitute of Immunology, PLA, Third Military Medical University, 400038, Chongqing, China.
Li WangInstitute of Immunology, PLA, Third Military Medical University, 400038, Chongqing, China.
Xinyuan ZhouInstitute of Immunology, PLA, Third Military Medical University, 400038, Chongqing, China.
Yuzhang WuInstitute of Immunology, PLA, Third Military Medical University, 400038, Chongqing, China.
Mengjie ChenSection of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, 60637, USA.
Beicheng SunDepartment of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210009, Jiangsu, China.
Bo ZhuInstitute of Cancer, Xinqiao Hospital, Third Military Medical University, 400038, Chongqing, China. bo.zhu@tmmu.edu.cn.
Jun HuangInstitute for Molecular Engineering, University of Chicago, Chicago, IL, 60637, USA. huangjun@uchicago.edu.
Lilin YeInstitute of Immunology, PLA, Third Military Medical University, 400038, Chongqing, China. yelilinlcmv@tmmu.edu.cn.ORCID http://orcid.org/0000-0003-0778-3311
Army Medical University · CNUniversity of Chicago · USNanjing Drum Tower Hospital · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetic modifications to histones dictate the differentiation of naïve CD4
Indexed as
Acute DiseaseAnimalsCell DifferentiationEnhancer of Zeste Homolog 2 ProteinLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMiceMice, TransgenicT-Lymphocytes, Helper-InducerEnhancer of Zeste Homolog 2 ProteinEzh2 protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.