Evidence map›Paper›PMID 30842626›Full record

ReviewCellular & molecular immunology2019

Sensing of physiological regulators by innate lymphoid cells.

Cyril Seillet, Nicolas Jacquelot

Open access · hybridAbstract readReview
In one paragraph

Review in Cellular & molecular immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 21 citations in OpenAlex.

  1. EngineeredAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2026
    Article
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  3. Article
  4. Review
  5. Review
  6. Article
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  10. AHR in the intestinal microenvironment: safeguarding barrier function.Nature reviews. Gastroenterology & hepatology · 2021
    Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Innate Lymphocytes in Inflammatory Arthritis.Frontiers in immunology · 2020
    Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Cyril SeilletMolecular Immunology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, 3052, Australia. seillet@wehi.edu.au.ORCID http://orcid.org/0000-0002-0941-8679
Nicolas JacquelotMolecular Immunology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, 3052, Australia.
The University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maintenance of homeostasis and immune protection rely  on the coordinated action of different physiological systems. Bidirectional communication between the immune system and physiological systems is required to sense and restore any disruption of equilibrium. Recent transcriptomic analyses of innate lymphoid cells (ILCs) from different tissues have revealed that ILCs express a large array of receptors involved in the recognition of neuropeptides, hormones and metabolic signals. ILCs rapidly secrete effector cytokines that are central in the development and activation of early immune responses, but they also constitutively secrete mediators that are important for tissue homeostasis. To achieve these functions effectively, ILCs integrate intrinsic and extrinsic signals that modulate their constitutive and induced activity. Disruption of the regulation of ILCs by physiological regulators leads to altered immune responses with harmful consequences for the organism. An understanding of these complex interactions between the immune system and physiological mediators is crucial to decipher the events leading to the protective versus pathological effects of these cells.

Indexed as

AnimalsCellular MicroenvironmentCytokinesGene Expression ProfilingHomeostasisHormonesHumansImmunity, InnateLymphocytesNeuropeptidesCytokinesHormonesNeuropeptideshomeostasisimmune protectionimmunityinnate lymphoid cells

Identifiers

PMID30842626
PMCPMC6474201
OpenAlexW2919873986

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.