Evidence map›Paper›PMID 30842613›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2019

Central blockade of the AT1 receptor attenuates pressor effects via reduction of glutamate release and downregulation of NMDA/AMPA receptors in the rostral ventrolateral medulla of rats with stress-induced hypertension.

Xuan Zhou, Hongyu Yang, Xiaoshan Song, Jijiang Wang, Linlin Shen, Jin Wang

Abstract read
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In one paragraph

Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
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  12. Article
  13. GABA is a mediator of brain ATHypertension research : official journal of the Japanese Society of Hypertension · 2020
    Review
  14. Angiotensin-II-mediated ATHypertension research : official journal of the Japanese Society of Hypertension · 2020
    Article
  15. Review
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xuan ZhouDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Hongyu YangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Xiaoshan SongDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Jijiang WangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Linlin ShenDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Jin WangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China. wangjin@shmu.edu.cn.
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glutamatergic activity in the rostral ventrolateral medulla (RVLM), which is an important brain area where angiotensin II (Ang II) elicits its pressor effects, contributes to the onset of hypertension. The present study aimed to explore the effect of central Ang II type 1 receptor (AT

Indexed as

Angiotensin IIAngiotensin II Type 1 Receptor BlockersAnimalsGlutamic AcidHypertensionMaleMedulla OblongataRats, Sprague-DawleyReceptor, Angiotensin, Type 1Receptors, Ionotropic GlutamateStress, PsychologicalAngiotensin IIAngiotensin II Type 1 Receptor BlockersGlutamic AcidReceptor, Angiotensin, Type 1Receptors, Ionotropic GlutamateAngiotensin II type 1 receptorGlutamatergic neuronsNMDA/AMPA receptorRostral ventrolateral medullaStress-induced hypertension

Identifiers

PMID30842613
OpenAlexW2921160324

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.