Evidence map›Paper›PMID 30842570›Full record

Observational studyScientific reports2019

Impact of laterality and mucinous histology on relapse-free and overall survival in a registry-based colon cancer series.

Francesca Negri, Annamaria De Giorgi, Annalisa Gilli, Cinzia Azzoni, Lorena Bottarelli, Letizia Gnetti, Matteo Goldoni, Laura Manotti, Paolo Sgargi, Maria Michiara and 4 more

Abstract readObservational Study
In one paragraph

Observational study in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Expression of VISTA on T cells in patients with cancer colon.Journal of the Egyptian National Cancer Institute · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Francesca NegriMedical Oncology Unit, University Hospital of Parma, Parma, 43126, Italy. francescanegri2@hotmail.com.
Annamaria De GiorgiMedical Oncology Unit, University Hospital of Parma, Parma, 43126, Italy.
Annalisa GilliMedical Oncology Unit, University Hospital of Parma, Parma, 43126, Italy.
Cinzia AzzoniDepartment of Medicine and Surgery, Unit of Pathological Anatomy, University Hospital of Parma, Parma, 43126, Italy.
Lorena BottarelliDepartment of Medicine and Surgery, Unit of Pathological Anatomy, University Hospital of Parma, Parma, 43126, Italy.
Letizia GnettiDepartment of Medicine and Surgery, Unit of Pathological Anatomy, University Hospital of Parma, Parma, 43126, Italy.
Matteo GoldoniMedical Statistics, Department of Medicine and Surgery, University of Parma, Parma, 43126, Italy.ORCID 0000-0002-1342-3921
Laura ManottiPathology Unit, Istituti Ospitalieri di Cremona, Cremona, 26100, Italy.
Paolo SgargiMedical Oncology Unit, University Hospital of Parma, Parma, 43126, Italy.
Maria MichiaraMedical Oncology Unit, University Hospital of Parma, Parma, 43126, Italy.
Francesco LeonardiMedical Oncology Unit, University Hospital of Parma, Parma, 43126, Italy.
Guido RindiInstitute of Anatomic Pathology, Catholic University, Rome, 00168, Italy.ORCID 0000-0003-2996-4404
Stefano CascinuDepartment of Medical and Surgical Sciences for Children and Adults, Division of Medical Oncology, Policlinico di Modena Azienda Ospedaliero-Universitaria di Modena, Modena, 41124, Italy.
Enrico Maria SiliniDepartment of Medicine and Surgery, Unit of Pathological Anatomy, University Hospital of Parma, Parma, 43126, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent data suggest that tumor laterality and mucinous histology may be clinically relevant. We investigated how both variables impact on the prognosis and the response to therapies in a large population-based cohort of cancer patients. Incidence data, clinical and pathological features, and outcome were systematically collected from the Tumor Registry of Parma over the years 2004-2009. Survival data were modeled by multivariable analysis. 1358 patients affected by stage I-IV colon cancer were considered; 661 (49%) had right-sided and 697 (51%) left-sided tumors. 144 (11%) had mucinous (MAC) and 1214 (89%) non-mucinous (NMAC) histology. MACs and NMACs of the right colon showed no difference in stage distribution, whereas left colon MACs were more frequently in an advanced stage (stage IV) (p = 0.008). Stage IV right colon tumors had a poorer overall survival than stage IV left-sided colon cancers (75

Indexed as

Adenocarcinoma, MucinousAgedAntineoplastic AgentsColorectal NeoplasmsFemaleHumansItalyMaleMiddle AgedMultivariate AnalysisNeoplasm Recurrence, LocalRetrospective StudiesSurvival RateAntineoplastic Agents

Identifiers

PMID30842570
PMCPMC6403425

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.