Evidence map›Paper›PMID 30842494›Full record

ArticleScientific reports2019

Systems Genetics of Hepatic Metabolome Reveals Octopamine as a Target for Non-Alcoholic Fatty Liver Disease Treatment.

Francois Brial, Aurélie Le Lay, Lyamine Hedjazi, Tsz Tsang, Jane F Fearnside, Georg W Otto, Fawaz Alzaid, Steven P Wilder, Nicolas Venteclef, Jean-Baptiste Cazier and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Assisted Fermentation by a ModifiedFood science & nutrition · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 12 institutions in 5 countries.

Francois BrialSorbonne University, University Paris Descartes, University Paris Diderot, INSERM UMR_S 1138, Cordeliers Research Centre, 75006, Paris, France.
Aurélie Le LaySorbonne University, University Paris Descartes, University Paris Diderot, INSERM UMR_S 1138, Cordeliers Research Centre, 75006, Paris, France.
Lyamine HedjaziSorbonne University, University Paris Descartes, University Paris Diderot, INSERM UMR_S 1138, Cordeliers Research Centre, 75006, Paris, France.
Tsz TsangComputational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, SW7 2AZ, United Kingdom.
Jane F FearnsideSchool of Health and Related Research, The University of Sheffield, 30 Regent Court, Sheffield, S10 2TA, United Kingdom.
Georg W OttoGenetics and Genomic Medicine, University College London Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, United Kingdom.
Fawaz AlzaidSorbonne University, University Paris Descartes, University Paris Diderot, INSERM UMR_S 1138, Cordeliers Research Centre, 75006, Paris, France.ORCID 0000-0003-3056-3640
Steven P WilderThe Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, OX3 7BN, United Kingdom.
Nicolas VenteclefSorbonne University, University Paris Descartes, University Paris Diderot, INSERM UMR_S 1138, Cordeliers Research Centre, 75006, Paris, France.
Jean-Baptiste CazierCentre for Computational Biology, Medical School, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
Jeremy K NicholsonComputational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, SW7 2AZ, United Kingdom.
Chris DayFaculty of Medical Sciences, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, United Kingdom.
Alastair D BurtFaculty of Medical Sciences, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, United Kingdom.
Ivo G GutCNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri Reixac 4, 08028, Barcelona, Spain.
Mark LathropMcGill University and Genome Quebec Innovation Centre, 740 Doctor Penfield Avenue, Montreal, QC, H3A 0G1, Canada.
Marc-Emmanuel DumasComputational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, SW7 2AZ, United Kingdom.ORCID 0000-0001-9523-7024
Dominique GauguierSorbonne University, University Paris Descartes, University Paris Diderot, INSERM UMR_S 1138, Cordeliers Research Centre, 75006, Paris, France. dominique.gauguier@inserm.fr.
Inserm · FRMcGill University and Génome Québec Innovation Centre · CACentre for Genomic Regulation · ESCentre for Human Genetics · GBDélégation Paris 5 · FRImperial College London · GBMurdoch University · AUNewcastle University · GBThe University of Adelaide · AUUniversity College London · GBUniversity of Birmingham · GBUniversity of Sheffield · GB

Funding

Wellcome TrustWellcome Trust 057733Wellcome Trust 066786
6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) is often associated with obesity and type 2 diabetes. To disentangle etiological relationships between these conditions and identify genetically-determined metabolites involved in NAFLD processes, we mapped

Indexed as

Polymorphism, Single NucleotideAnimalsChromosomes, MammalianDiet, High-FatMaleMetabolomicsMice, Inbred BALB CNon-alcoholic Fatty Liver DiseaseOctopamineProton Magnetic Resonance SpectroscopyQuantitative Trait LociSystems BiologyTreatment OutcomeOctopamine

Identifiers

PMID30842494
PMCPMC6403227
OpenAlexW2918719541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.