ArticleScientific reports2019
Microbial Degradation of Nicotinamide by a Strain Alcaligenes sp. P156.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- The Therapeutic Potential of Orange Juice in Cardiac Remodeling: A Metabolomics Approach.Metabolites · 2025Article
- Integrating uterine microbiome and metabolome to advance the understanding of the uterine environment in dairy cows with metritis.Animal microbiome · 2024Article
- Carboxypeptidase G and pterin deaminase metabolic pathways degrade folic acid in Variovorax sp. F1.BMC microbiology · 2022Article
- Sustainable Design of New Ionic Forms of Vitamin BJournal of agricultural and food chemistry · 2022Article
- A simple, efficient and rapid screening technique for differentiating nitrile hydratase and nitrilase producing bacteria.Biotechnology reports (Amsterdam, Netherlands) · 2019Article
- Isolation of a 3-hydroxypyridine degrading bacterium, Agrobacterium sp. DW-1, and its proposed degradation pathway.AMB Express · 2019Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
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Abstract
A novel Alcaligenes sp. strain P156, which can utilize nicotinamide as its sole source of carbon, nitrogen and energy, was enriched and isolated from soil in a solid waste treatment plant. Aerobic growth and degradation with nicotinamide were characterized. Seven nicotinamide degradation-related genes were obtained by sequence alignment from the genome sequence of strain P156. Four genes, designated naaA, naaD, naaE and naaF, were cloned and heterologously expressed. Nicotinamide degradation is initiated by deamination to form nicotinic acid catalyzed by the nicotinamidase NaaA, which shares highest amino acid sequence identity (27.2%) with nicotinamidase from Arabidopsis thaliana. Nicotinic acid is converted to 6-hydroxynicotinic acid, which is further oxidized to 2,5-dihydroxypyridine (2,5-DHP). 2,5-DHP is then transformed to a ring-cleavage product, N-formylmaleamic acid, by an Fe
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