Evidence map›Paper›PMID 30842346›Full record

ArticleSexually transmitted infections2019

Syphilis associated with recreational drug use, depression and high-risk sexual behaviour in men who have sex with men: a case-control study in China.

Huichao Wu, Cuizhen Xiu, Xiaojing Fu, Menglong Li, Zhenhong Wang, Xiufang Li, Jing Wu, Sten H Vermund, Yifei Hu

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sexually transmitted infections, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04706624 (Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04706624 nacompletednot on this mapstarted 2021, after this paper: background citation

Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics

TypeinterventionalSponsorHanoi Medical UniversityRan2021 to 2025Enrolled667ConditionsMethamphetamine Abuse, Opioid-use Disorder, HIV SeropositivityArmsContingency management (12 weeks), Contingency management (6 weeks), SMS reminders, Matrix only, Matrix + Contingency management
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Huichao Wu *Child and Adolescent Health and Maternal Health, School of Public Health, Capital Medical University, Beijing, China, Beijing, China.
Cuizhen Xiu *Department of HIV/STD Prevention and Control, Qingdao Center for Disease Control and Prevention, Qingdao, China.
Xiaojing FuDivision of Biostatistics, School of Public Health and Management, Weifang Medical University, Weifang, China.
Menglong LiChild and Adolescent Health and Maternal Health, School of Public Health, Capital Medical University, Beijing, China, Beijing, China.
Zhenhong WangDepartment of Dermatology, The Third Hospital of Chengyang, Qingdao, China.
Xiufang LiThe Sex Center, The Affiliated Hospital of Medical College Qingdao University, Qingdao, China.
Jing WuSchool of Agroforestry and Medicine, The Open University of China, Beijing, China.
Sten H VermundYale School of Public Health, Yale University, New Haven, Connecticut, USA.
Yifei HuChild and Adolescent Health and Maternal Health, School of Public Health, Capital Medical University, Beijing, China, Beijing, China huyifei@yahoo.com.ORCID 0000-0002-4611-2206
Capital Medical University · CNDeyang Stomatological Hospital · CNOpen University of China · CNQingdao Municipal Center for Disease Control and Prevention · CNQingdao University · CNWeifang Medical University · CNYale University · US

Funding

Ujima Mentoring ProgramP30MH062246 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 2001 to 2026
$57.4M
Using Coincidence Analysis to Investigate Factors Affecting PrEP Initiation and Continuation in Southern ending the Epidemic CountiesP30MH062294 · NIMH · YALE UNIVERSITY · PI E. Jennifer Edelman · 2001 to 2026
$48.5M
NIMH NIH HHS P30 MH062294
6 · The paper itself

Abstract

objectiveWe investigated syphilis prevalence among men who have sex with men (MSM) in China, as well as potential risk factors. Our principal hypothesis was that syphilis would be associated with the use of recreational drugs such as methamphetamines.

methodsFrom April to October 2013, we used several methods to recruit MSM in Qingdao, collecting demographic/behavioural information via self-administrated questionnaires. Trained health workers collected blood for the

resultsWe recruited 447 MSM who agreed to participate and who completed syphilis testing. Of 71 (15.9%) syphilis-positive MSM, 44 (62.0%) used drugs. Of 376 (84.1%) syphilis-negative MSM, 186 (49.5%) used drugs. We found a positive association with syphilis for any recreational drug use (crude OR (cOR) 1.7, 95 % CI 1.0 to 2.8), frequent methamphetamine use (cOR 2.4, 95% CI 1.1 to 5.3) and multiple drug use (adjusted OR (aOR) 3.4, 95% CI 1.3 to 9.2). Syphilis-positive men were more likely to have a higher physical depression score (aOR 5.2, 95% CI 1.1 to 24.4), be > 30 years old (aOR 2.7, 95% CI 1.5 to 4.8), report a prior STI (aOR 4.1, 95% CI 2.3 to 7.3) and report a sex party experience (aOR 2.2, 95% CI 1.1 to 4.4).

conclusionsRecreational drug use, depression and high-risk sexual behaviours were associated with syphilis infection among MSM in China. Only a multifaceted approach is likely be effective in control of both syphilis and HIV .

Indexed as

Homosexuality, MaleSexual BehaviorAdultCase-Control StudiesChinaDemographyHumansLogistic ModelsMaleSexually Transmitted DiseasesSubstance-Related DisordersSurveys and QuestionnairesSyphilisSyphilis SerodiagnosisYoung AdultChinadepressionmen who have sex with menmethamphetaminesexual behavioursyphilis

Identifiers

PMID30842346
PMCPMC11093516
OpenAlexW2921524249

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.