ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Sequential Neural Activity in Primary Motor Cortex during Sleep.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 59 citations in OpenAlex.
- Sleep firing rate homeostasis is disrupted in mild parkinsonism.NPJ Parkinson's disease · 2026Article
- Excessive daytime sleepiness in parkinsonism is associated with cortical and basal ganglia beta oscillatory activity.Communications biology · 2026Article
- Medial prefrontal cortex activity precedes dorsomedial striatum in need for change during history-based flexible behavior.iScience · 2025Article
- RHO GTPase by L1 GABAergic neurons in frontal cortex and L6 glutamatergic neurons in prefrontal cortex differentiates states of unconsciousness.Scientific reports · 2025Article
- Home-Cage Training for Non-Human Primates: An Opportunity to Reduce Stress and Study Natural Behavior in Neurophysiology Experiments.Animals : an open access journal from MDPI · 2025Review
- Monitoring Sleep Quality Through Low α-Band Activity in the Prefrontal Cortex Using a Portable Electroencephalogram Device: Longitudinal Study.Journal of medical Internet research · 2025Article
- Song-like activation of syringeal and respiratory muscles during sleep in canaries.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025Article
- Article
- Neural Oscillations in the Somatosensory and Motor Cortex Distinguish Dexmedetomidine-Induced Anesthesia and Sleep in Rats.CNS neuroscience & therapeutics · 2025Article
- Machine learning-based high-frequency neuronal spike reconstruction from low-frequency and low-sampling-rate recordings.Nature communications · 2024Article
- Slow-wave sleep dysfunction in mild parkinsonism is associated with excessive beta and reduced delta oscillations in motor cortex.Frontiers in neuroscience · 2024Article
- Home-Enclosure-Based Behavioral and Wireless Neural Recording Setup for Unrestrained Rhesus Macaques.eNeuro · 2023Article
- Local field potentials and single unit dynamics in motor cortex of unconstrained macaques during different behavioral states.Frontiers in neuroscience · 2023Article
- Conserved Population Dynamics in the Cerebro-Cerebellar System between Waking and Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Review
- Brain states in freely behaving marmosets.Sleep · 2022Article
- Learned Motor Patterns Are Replayed in Human Motor Cortex during Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Modulating role of serotonergic signaling in sleep and memory.Pharmacological reports : PR · 2022Review
- Improving online and offline gain from repetitive practice using anodal tDCS at dorsal premotor cortex.NPJ science of learning · 2021Article
- Communication from the cerebellum to the neocortex during sleep spindles.Progress in neurobiology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Sequential firing of neurons during sleep is thought to play a role in the consolidation of learning. However, direct evidence for such sequence replay is limited to only a few brain areas and sleep states mainly in rodents. Using a custom-designed wearable neural data logger and chronically implanted electrodes, we made long-term recordings of neural activity in the primary motor cortex of two female nonhuman primates during free behavior and natural sleep. We used the local field potential (LFP) spectrogram to characterize sleep cycles, and examined firing rates, correlations, and sequential firing of neurons at different frequency bands through the cycle. Slow-wave sleep (SWS) was characterized by low neural firing rates and high synchrony, reflecting slow oscillations between cortical down and up states. However, the order in which neurons entered up states was similar to the sequence of neural activity observed at low frequencies during waking behavior. In addition, we found evidence of brief bursts of theta oscillation, associated with non-SWS states, during which neurons fired in strikingly regular sequential order phase-locked to the LFP. Theta sequences were preserved between waking and sleep, but appeared not to resemble the order of neural activity observed at lower frequencies. The sequential firing of neurons during slow oscillations and theta bursts may contribute to the consolidation of procedural memories during sleep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.