ArticleBMJ open2019
Patterns of statin utilisation for new users and market dynamics in South Korea: a 13-year retrospective cohort study.
Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Association Between Statin Use and Glaucoma Risk: A Population-Based Study.Investigative ophthalmology & visual science · 2025Article
- Association of Ezetimibe and Statin Combinations With Recurrent Ischemic Stroke: A Nationwide Study With Dual Design.Journal of the American Heart Association · 2025Article
- Association Between Long-term Statin Therapy and New-onset Diabetes in Cardiovascular Risk Patients in the UAE.Oman medical journal · 2024Article
- Effects of statin use on serum creatinine phosphokinase levels in normal thyroid function.The Korean journal of internal medicine · 2024Article
- Possible link between statin and iron deficiency anemia: A South Korean nationwide population-based cohort study.Science advances · 2023Article
- Population health outcomes in South Korea 1990-2019, and projections up to 2040: a systematic analysis for the Global Burden of Disease Study 2019.The Lancet. Public health · 2023Article
- Incidence in pharmacoepidemiology: A conceptual framework for incidence of a single substance or group of substances with statins as an example.Basic & clinical pharmacology & toxicology · 2023Article
- Association between Gout and Dyslipidemia: A Nested Case-Control Study Using a National Health Screening Cohort.Journal of personalized medicine · 2022Article
- Real-world Evidence for Adherence and Persistence with Atorvastatin Therapy.Cardiology and therapy · 2021Review
- Impact of Prior Statin Use on Reperfusion Rate and Stroke Outcomes in Patients Receiving Endovascular Treatment.Journal of clinical medicine · 2021Article
- Co-Administration of Vonoprazan, Not Tegoprazan, Affects the Pharmacokinetics of Atorvastatin in Healthy Male Subjects.Frontiers in pharmacology · 2021Article
- Is greater generic competition also linked to lower drug prices in South Korea?Health economics review · 2020Article
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Authors and funding
2 authors.
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Abstract
objectiveThis study analysed utilisation of statins for new statin users and assessed market dynamics of statins in South Korea.
designThis study is a retrospective cohort study.
settingThe yearly claims data for statins were retrieved from the National Health Insurance Service-National Sample Cohort.
main outcome measureWe are interested in new statin users during 2003-2015 in Korea. Information on prescribed statins, including intensity of statins and entry of new and follow-on statins in the market, and healthcare institutions that prescribed the statins were also collected. In time series analysis, we estimated the effect of introduction of generics in the market, specifically for newly prescribed statin users.
resultsThis 13-year longitudinal study of a sample cohort provided by the National Health Insurance Service found that the incidence of new statin user increase from 838.1/100 000 persons in 2003 to 1626.9/100 000 persons in 2015. Most new users were initiated on a monotherapy that was prescribed at primary healthcare institutions. However, the statin market for new users were quite dynamic in Korea. First, the most commonly prescribed statin changed several times during the study period. Second, the use of moderate-intensity statins increased from 57% in 2003 to 92% in 2015. In line with this result, we could not observe substantial differences in prescription of statins in groups having selected diseases history. Lastly, we found market invasion or switch of statins among new statin users, specifically at primary healthcare institutions.
conclusionSimilar to other countries, the incidence of new statin users has been increased in Korea. However, the statin market in Korea is quite dynamic compared with other countries. Interestingly, discounted price of originals after the introduction of generics immediately expand markets or substitute the market particularly in primary healthcare institutions in Korea.
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