Evidence map›Paper›PMID 30842065›Full record

ArticleBMJ (Clinical research ed.)2019

Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction: mendelian randomisation study in UK Biobank.

Shan Luo, Shiu Lun Au Yeung, Jie V Zhao, Stephen Burgess, C Mary Schooling

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ (Clinical research ed.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 6 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 6 syntheses or guidelines pooled it, 126 citations in OpenAlex.

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  19. Genetic links between atopy, allergy, and alopecia areata: insights from a Mendelian randomization study.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2024
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Shan LuoSchool of Public Health, University of Hong Kong, Hong Kong SAR, China.
Shiu Lun Au YeungSchool of Public Health, University of Hong Kong, Hong Kong SAR, China.
Jie V ZhaoSchool of Public Health, University of Hong Kong, Hong Kong SAR, China.
Stephen BurgessCardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
C Mary SchoolingSchool of Public Health, University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0001-9933-5887
University of Hong Kong · HKCity University of New York · USUniversity of Cambridge · GB

Funding

British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946Medical Research Council MC_UU_00002/7
6 · The paper itself

Abstract

objectiveTo determine whether endogenous testosterone has a causal role in thromboembolism, heart failure, and myocardial infarction.

designTwo sample mendelian randomisation study using genetic variants as instrumental variables, randomly allocated at conception, to infer causality as additional randomised evidence.

settingReduction by Dutasteride of Prostate Cancer Events (REDUCE) randomised controlled trial, UK Biobank, and CARDIoGRAMplusC4D 1000 Genomes based genome wide association study.

participants3225 men of European ancestry aged 50-75 in REDUCE; 392 038 white British men and women aged 40-69 from the UK Biobank; and 171 875 participants of about 77% European descent, from CARDIoGRAMplusC4D 1000 Genomes based study for validation.

main outcome measuresThromboembolism, heart failure, and myocardial infarction based on self reports, hospital episodes, and death.

resultsOf the UK Biobank participants, 13 691 had thromboembolism (6208 men, 7483 women), 1688 had heart failure (1186, 502), and 12 882 had myocardial infarction (10 136, 2746). In men, endogenous testosterone genetically predicted by variants in the

conclusionsEndogenous testosterone was positively associated with thromboembolism, heart failure, and myocardial infarction in men. Rates of these conditions are higher in men than women. Endogenous testosterone can be controlled with existing treatments and could be a modifiable risk factor for thromboembolism and heart failure.

Indexed as

AdultAgedBiological Specimen BanksFemaleGenetic PleiotropyGenetic VariationGenome-Wide Association StudyHeart FailureHumansMaleMendelian Randomization AnalysisMiddle AgedMyocardial InfarctionOdds RatioRandomized Controlled Trials as TopicRisk FactorsTestosterone

Identifiers

PMID30842065
PMCPMC6402044
OpenAlexW2913651649

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.