ArticleMetabolites2019
Ageing Investigation Using Two-Time-Point Metabolomics Data from KORA and CARLA Studies.
Article in Metabolites, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 47 citations in OpenAlex.
- Amino acid-based biological age clock and its implications for human health and aging.Nature communications · 2026Article
- Aging-linked systemic lipid signature is reprogrammed by caloric restriction in rhesus monkeys.Molecular systems biology · 2026Article
- Prospective association between plasma amino acids and healthy aging in older adults.Journal of internal medicine · 2025Article
- LEOPARD: missing view completion for multi-timepoint omics data via representation disentanglement and temporal knowledge transfer.Nature communications · 2025Article
- Robust Metabolomic Age Prediction Based on a Wide Selection of Metabolites.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Towards Healthy Longevity: Comprehensive Insights from Molecular Targets and Biomarkers to Biological Clocks.International journal of molecular sciences · 2024Review
- Targeted metabolomics reveals plasma biomarkers and metabolic alterations of the aging process in healthy young and older adults.GeroScience · 2023Article
- A framework of biomarkers for vascular aging: a consensus statement by the Aging Biomarker Consortium.Life medicine · 2023Article
- The Transport and Uptake of Resveratrol Mediated via Glucose Transporter 1 and Its Antioxidant Effect in Caco-2 Cells.Molecules (Basel, Switzerland) · 2023Article
- Metabolomics Profiling of Age-Associated Metabolites in Malay Population.Oxidative medicine and cellular longevity · 2023Article
- The Aging Process: A Metabolomics Perspective.Molecules (Basel, Switzerland) · 2022Article
- The metabolomics of human aging: Advances, challenges, and opportunities.Science advances · 2022Review
- Article
- Lipidome- and Genome-Wide Study to Understand Sex Differences in Circulatory Lipids.Journal of the American Heart Association · 2022Article
- Associations of the Lipidome with Ageing, Cognitive Decline and Exercise Behaviours.Metabolites · 2022Review
- A Metabolomic Aging Clock Using Human Cerebrospinal Fluid.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Effect of dietary protein content shift on aging in elderly rats by comprehensive quantitative score and metabolomics analysis.Frontiers in nutrition · 2022Article
- Cardiovascular risk factors, living and ageing in Halle: the CARLA study.European journal of epidemiology · 2022Article
- Integrated Multi-Omics for Novel Aging Biomarkers and Antiaging Targets.Biomolecules · 2021Review
- Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort.BMC medicine · 2021Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
Ageing, one of the largest risk factors for many complex diseases, is highly interconnected to metabolic processes. Investigating the changes in metabolite concentration during ageing among healthy individuals offers us unique insights to healthy ageing. We aim to identify ageing-associated metabolites that are independent from chronological age to deepen our understanding of the long-term changes in metabolites upon ageing. Sex-stratified longitudinal analyses were performed using fasting serum samples of 590 healthy KORA individuals (317 women and 273 men) who participated in both baseline (KORA S4) and seven-year follow-up (KORA F4) studies. Replication was conducted using serum samples of 386 healthy CARLA participants (195 women and 191 men) in both baseline (CARLA-0) and four-year follow-up (CARLA-1) studies. Generalized estimation equation models were performed on each metabolite to identify ageing-associated metabolites after adjusting for baseline chronological age, body mass index, physical activity, smoking status, alcohol intake and systolic blood pressure. Literature researches were conducted to understand their biochemical relevance. Out of 122 metabolites analysed, we identified and replicated five (C18, arginine, ornithine, serine and tyrosine) and four (arginine, ornithine, PC aa C36:3 and PC ae C40:5) significant metabolites in women and men respectively. Arginine decreased, while ornithine increased in both sexes. These metabolites are involved in several ageing processes: apoptosis, mitochondrial dysfunction, inflammation, lipid metabolism, autophagy and oxidative stress resistance. The study reveals several significant ageing-associated metabolite changes with two-time-point measurements on healthy individuals. Larger studies are required to confirm our findings.
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