Evidence map›Paper›PMID 30841603›Full record

ArticleAnimals : an open access journal from MDPI2019

Health Benefits of Supplementing Nursery Pig Diets with Microalgae or Fish Oil.

Alison V Lee, Lan You, Se-Young Oh, Ziwei Li, Alexandra Code, Cuilan Zhu, Rebecca E Fisher-Heffernan, Timothy R H Regnault, Cornelis F M De Lange, Lee-Anne Huber and 1 more

Open access · goldAbstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 38 citations in OpenAlex.

  1. Effects ofInternational journal of environmental research and public health · 2022
    Trial
  2. Review
  3. Nutritional Value ofAnimals : an open access journal from MDPI · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Alison V LeeDepartment of Animal Biosciences, University of Guelph, ON N1G 2W1, Canada. alee09@uoguelph.ca.
Lan YouDepartment of Animal Biosciences, University of Guelph, ON N1G 2W1, Canada. youlan0803@gmail.com.
Se-Young OhDepartment of Animal Biosciences, University of Guelph, ON N1G 2W1, Canada. ugohs530@gmail.com.
Ziwei LiDepartment of Animal Biosciences, University of Guelph, ON N1G 2W1, Canada. zli05@uoguelph.ca.
Alexandra CodeDepartment of Animal Biosciences, University of Guelph, ON N1G 2W1, Canada. acode@uoguelph.ca.
Cuilan ZhuDepartment of Animal Biosciences, University of Guelph, ON N1G 2W1, Canada. czhu@uoguelph.ca.
Rebecca E Fisher-HeffernanDepartment of Animal Biosciences, University of Guelph, ON N1G 2W1, Canada. rfisher01@gmail.com.
Timothy R H RegnaultDepartment of Obstetrics and Gynecology and Physiology and Pharmacology, Western University, London, ON N6A 5C1, Canada. tim.regnault@uwo.ca.ORCID 0000-0003-1930-8358
Cornelis F M De LangeDepartment of Animal Biosciences, University of Guelph, ON N1G 2W1, Canada. cdelange@uoguelph.ca.
Lee-Anne HuberDepartment of Animal Biosciences, University of Guelph, ON N1G 2W1, Canada. huberl@uoguelph.ca.
Niel A KarrowDepartment of Animal Biosciences, University of Guelph, ON N1G 2W1, Canada. nkarrow@uoguelph.ca.
University of Guelph · CAWestern University · CA

Funding

Alltech 52363Natural Sciences and Engineering Research Council of Canada 401018Ontario Ministry of Agriculture, Food and Rural Affairs 401018Swine Innovation Porc 1239e
6 · The paper itself

Abstract

Weaning stress can negatively impact a pig's performance; dietary supplementation with omega-3 polyunsaturated fatty acids (n-3 PUFA) reduces inflammatory stress and promotes nursery pig's health and growth. Fish oil (FO) is a major source of n-3 PUFA; however, microalgae (AL) may provide an alternative source of n-3 PUFA. The aim of this study was to assess the health benefits of supplementing a plant protein-based nursery diet with 3.12% AL or 1.25% FO providing equal total n-3 PUFA compared to a control (CON) diet. Seventy-two pigs were fed experimental diets for three weeks (phases 1 and 2), followed by a common standard diet for three weeks (phase 3). Following phase 2, 8 pigs per treatment underwent a lipopolysaccharide (LPS) immune stress challenge to assess the acute-phase response and 8 pigs per treatment were vaccinated with novel antigens to assess acquired immunity. No significant differences in piglets' growth were observed, despite decreased feed intake in FO piglets compared to AL piglets in phase 3. AL supplementation tended to reduce, and FO supplementation significantly reduced the LPS-induced fever response. The AL pigs had significantly reduced cortisol responses, increased cytokine concentrations, and increased chromogranin A concentrations compared to FO and CON pigs following LPS challenge. Results suggest that AL or FO supplementation in nursery diets differentially modulate the acute-phase response, possibly due to different n-3 PUFA profiles between the two ingredients.

Indexed as

acute-phase responsefish oilimmune responselipopolysaccharidemicroalgaeswine nutrition

Identifiers

PMID30841603
PMCPMC6465993
OpenAlexW2919013828

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.