ArticleInternational journal of molecular sciences2019
Bone Marrow Aspirate Concentrate for the Treatment of Avascular Meniscus Tears in a One-Step Procedure-Evaluation of an In Vivo Model.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Current practice of biologic augmentation techniques to enhance the healing of meniscal repairs: A collaborative survey within the Meniscus International Network (MenIN) Study Group.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- Biologic Augmentation for Meniscus Repair: A Narrative Review.Bioengineering (Basel, Switzerland) · 2026Review
- Secretome from human placenta-derived mesenchymal stem cells repairs mechanically induced meniscus injury in mice by activating the proliferation and suppressing the apoptosis of endogenous meniscus progenitor cells.Stem cell research & therapy · 2025Article
- Research Progress of Bone Grafting: A Comprehensive Review.International journal of nanomedicine · 2025Review
- Current advances in animal model of meniscal injury: From meniscal injury to osteoarthritis.Journal of orthopaedic translation · 2025Review
- Augmentation with Bone Marrow Aspirate Harvested from the Iliac Crest for Horizontal or Radial Meniscal Tears Yields Favorable Healing Rates in Magnetic Resonance Imaging and Clinical Outcomes.Clinics in orthopedic surgery · 2024Article
- Development of a novel approach for restoration of the meniscus using silk-elastin in a rabbit meniscus injury model.BMC musculoskeletal disorders · 2024Article
- Article
- Molecular Biology of Meniscal Healing: A Narrative Review.International journal of molecular sciences · 2024Review
- Meniscus Allograft Transplantation Augmented With Autologous Bone Marrow Aspirate Concentrate.Arthroscopy techniques · 2023Article
- The Current Role of Biologics for Meniscus Injury and Treatment.Current reviews in musculoskeletal medicine · 2022Review
- Regeneration of meniscal avascular zone using autogenous meniscal fragments in a rabbit model.BMC surgery · 2022Article
- Meniscus repair: up-to-date advances in stem cell-based therapy.Stem cell research & therapy · 2022Review
- Lateral Meniscus Allograft Transplantation in Combination with BMAC (Bone Marrow Aspirate Concentrate) Injection: Biologic Augmentation of the Allograft.Arthroscopy techniques · 2022Article
- Impact of the Process Variables on the Yield of Mesenchymal Stromal Cells from Bone Marrow Aspirate Concentrate.Bioengineering (Basel, Switzerland) · 2022Review
- Changes in the avascular area of the meniscus using mesenchymal stem cells and growth plate chondrocytes in a pig model.Journal of anatomy · 2021Article
- Blood in the joint: effects of hemarthrosis on meniscus health and repair techniques.Osteoarthritis and cartilage · 2021Review
- Fibronectin Adherent Cell Populations Derived From Avascular and Vascular Regions of the Meniscus Have Enhanced Clonogenicity and Differentiation Potential Under Physioxia.Frontiers in bioengineering and biotechnology · 2021Article
- Post-Traumatic Osteoarthritis Assessment in Emerging and Advanced Pre-Clinical Meniscus Repair Strategies: A Review.Frontiers in bioengineering and biotechnology · 2021Review
- Mechanically superior matrices promote osteointegration and regeneration of anterior cruciate ligament tissue in rabbits.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Avascular meniscus tears show poor intrinsic regenerative potential. Thus, lesions within this area predispose the patient to developing knee osteoarthritis. Current research focuses on regenerative approaches using growth factors or mesenchymal stem cells (MSCs) to enhance healing capacity within the avascular meniscus zone. The use of MSCs especially as progenitor cells and a source of growth factors has shown promising results. However, present studies use bone-marrow-derived BMSCs in a two-step procedure, which is limiting the transfer in clinical praxis. So, the aim of this study was to evaluate a one-step procedure using bone marrow aspirate concentrate (BMAC), containing BMSCs, for inducing the regeneration of avascular meniscus lesions. Longitudinal meniscus tears of 4 mm in size of the lateral New Zealand White rabbit meniscus were treated with clotted autologous PRP (platelet-rich plasma) or BMAC and a meniscus suture or a meniscus suture alone. Menisci were harvested at 6 and 12 weeks after initial surgery. Macroscopical and histological evaluation was performed according to an established Meniscus Scoring System. BMAC significantly enhanced regeneration of the meniscus lesions in a time-dependent manner and in comparison to the PRP and control groups, where no healing could be observed. Treatment of avascular meniscus lesions with BMAC and meniscus suturing seems to be a promising approach to promote meniscus regeneration in the avascular zone using a one-step procedure.
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Registered trials
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