ArticleJournal of clinical medicine2019
Functional Brain Network Topology Discriminates between Patients with Minimally Conscious State and Unresponsive Wakefulness Syndrome.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Managing disorders of consciousness: the role of electroencephalography.Journal of neurology · 2021Pooled it
- Advancing EEG-based assessment of consciousness and cognition in prolonged disorders of consciousness.Communications medicine · 2026Article
- EEG hemispheric asymmetry and behavioral responsiveness following rTMS in unresponsive wakefulness syndrome: an exploratory study.Journal of neuroengineering and rehabilitation · 2026Article
- Auditory paradigm-dependent EEG feature screening and representation for distinguishing consciousness states in male patients with disorders of consciousness.Frontiers in neurology · 2026Article
- Significance of the corpus callosum and inferior fronto-occipital fasciculus in recovery after traumatic brain injury.Neuroradiology · 2025Article
- Movement-related ERS and connectivity in the gamma frequency decrease with practice.NeuroImage · 2023Article
- Dysfunctional connectivity as a neurophysiologic mechanism of disorders of consciousness: a systematic review.Frontiers in neuroscience · 2023Review
- Disturbed functional connectivity and topological properties of the frontal lobe in minimally conscious state based on resting-state fNIRS.Frontiers in neuroscience · 2023Article
- Olfactory response is a potential sign of consciousness: electroencephalogram findings.Frontiers in neuroscience · 2023Article
- Stimulation-related modifications of evolving functional brain networks in unresponsive wakefulness.Scientific reports · 2022Article
- Frontal and parietal lobes play crucial roles in understanding the disorder of consciousness: A perspective from electroencephalogram studies.Frontiers in neuroscience · 2022Review
- tDCS-EEG for Predicting Outcome in Patients With Unresponsive Wakefulness Syndrome.Frontiers in neuroscience · 2022Article
- Narrative Review: Quantitative EEG in Disorders of Consciousness.Brain sciences · 2021Review
- Consciousness and complexity: a consilience of evidence.Neuroscience of consciousness · 2021Review
- Outcome Prediction in Unresponsive Wakefulness Syndrome and Minimally Conscious State by Non-linear Dynamic Analysis of the EEG.Frontiers in neurology · 2021Article
- Identification of the Key Regulators of Spina Bifida Through Graph-Theoretical Approach.Frontiers in genetics · 2021Article
- Diagnostic Developments in Differentiating Unresponsive Wakefulness Syndrome and the Minimally Conscious State.Frontiers in neurology · 2021Review
- Virtual Reality Based Cognitive Rehabilitation in Minimally Conscious State: A Case Report with EEG Findings and Systematic Literature Review.Brain sciences · 2020Review
- FRONTIERS IN DETECTING CONSCIOUSNESS: THE GROWING USE OF EEG ANALYSIS.Innovations in clinical neuroscience · 2020Article
- Toward Improving Diagnostic Strategies in Chronic Disorders of Consciousness: An Overview on the (Re-)Emergent Role of Neurophysiology.Brain sciences · 2020Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Consciousness arises from the functional interaction of multiple brain structures and their ability to integrate different complex patterns of internal communication. Although several studies demonstrated that the fronto-parietal and functional default mode networks play a key role in conscious processes, it is still not clear which topological network measures (that quantifies different features of whole-brain functional network organization) are altered in patients with disorders of consciousness. Herein, we investigate the functional connectivity of unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) patients from a topological network perspective, by using resting-state EEG recording. Network-based statistical analysis reveals a subnetwork of decreased functional connectivity in UWS compared to in the MCS patients, mainly involving the interhemispheric fronto-parietal connectivity patterns. Network topological analysis reveals increased values of local-community-paradigm correlation, as well as higher clustering coefficient and local efficiency in UWS patients compared to in MCS patients. At the nodal level, the UWS patients showed altered functional topology in several limbic and temporo-parieto-occipital regions. Taken together, our results highlight (i) the involvement of the interhemispheric fronto-parietal functional connectivity in the pathophysiology of consciousness disorders and (ii) an aberrant connectome organization both at the network topology level and at the nodal level in UWS patients compared to in the MCS patients.
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