ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019
Altered anticipation and processing of aversive interoceptive experience among women remitted from bulimia nervosa.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Altered anticipatory brain responses in eating disorders: A neuroimaging meta-analysis.European eating disorders review : the journal of the Eating Disorders Association · 2023Pooled it
- Self-reported interoceptive sensibility across eating disorder symptoms: associations with sociodemographic factors.Journal of eating disorders · 2026Article
- Global, regional and national level burden of bulimia nervosa from 1990 to 2021 and their projections to 2030: analysis of the global burden of disease study.Journal of eating disorders · 2025Article
- Perceptual Dysfunction in Eating Disorders.Current topics in behavioral neurosciences · 2025Review
- Neuroimaging studies of resting-state functional magnetic resonance imaging in eating disorders.BMC medical imaging · 2024Review
- Relationship Between Interoception and Autistic Traits: A Resting-State Functional Connectivity Study.Journal of autism and developmental disorders · 2024Article
- Transdiagnostic failure to adapt interoceptive precision estimates across affective, substance use, and eating disorders: A replication and extension of previous results.Biological psychology · 2024Article
- Evaluating the predictions of an interoceptive inference model of bulimia nervosa.Journal of eating disorders · 2024Article
- Exploring the thalamus: a crucial hub for brain function and communication in patients with bulimia nervosa.Journal of eating disorders · 2023Article
- Transdiagnostic failure to adapt interoceptive precision estimates across affective, substance use, and eating disorders: A replication study.medRxiv : the preprint server for health sciences · 2023Article
- Current Discoveries and Future Implications of Eating Disorders.International journal of environmental research and public health · 2023Review
- State-specific alterations in the neural computations underlying inhibitory control in women remitted from bulimia nervosa.Molecular psychiatry · 2023Article
- Parieto-occipital ERP indicators of gut mechanosensation in humans.Nature communications · 2023Article
- Genetics and neurobiology of eating disorders.Nature neuroscience · 2022Review
- Gastrointestinal Interoception in Eating Disorders: Charting a New Path.Current psychiatry reports · 2022Review
- Individual differences in sensory and expectation driven interoceptive processes: a novel paradigm with implications for alexithymia, disordered eating and obesity.Scientific reports · 2021Article
- Perceptual insensitivity to the modulation of interoceptive signals in depression, anxiety, and substance use disorders.Scientific reports · 2021Observational
- The Role of Disgust in Eating Disorders.Current psychiatry reports · 2021Review
- Brain Stimulation in Eating Disorders: State of the Art and Future Perspectives.Journal of clinical medicine · 2020Review
- Non-invasive cervical vagus nerve stimulation effects on reaction time and valence image anticipation response.Brain stimulationArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Bulimia nervosa (BN) is characterized by dysregulated intake of food, which may indicate homeostatic imbalance. Critically important for homeostatic regulation is interoception, or the sensing and processing of body-relevant information. A well-documented link between avoidance of unpleasant body sensations and BN symptoms suggests that aversive interoceptive experiences may be particularly relevant to BN pathophysiology. This study examined whether individuals with a history of BN show aberrant neural processing of aversive interoceptive stimuli. Using a cued inspiratory breathing load paradigm, we compared women remitted from BN (RBN; n = 24; to reduce the confounding effects of active bulimic symptoms) and control women (CW; n = 25). During breathing load anticipation, the RBN group, relative to CW, showed increased activation in mid-insula, superior frontal gyrus, putamen, dorsal anterior cingulate, posterior cingulate, and amygdala. However, over the course of the aversive experience, neural activation in RBN relative to CW showed an aberrant decline in most of these regions. Exploratory analyses indicated that greater activation during breathing load anticipation was associated with past bulimic symptom severity and the duration of symptom remission. An exaggerated anticipatory response and an abnormally decreasing response during aversive homeostatic perturbations may promote hallmark bulimic behaviors-binge eating, dietary restriction, and purging. Our findings support a role for homeostatic instability in BN, and these altered patterns of brain activation may serve as novel targets for pharmacological, neuromodulatory, and behavioral interventions.
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